fumagillin


Also found in: Encyclopedia, Wikipedia.

fumagillin

(fū″mă-jĭl′ĭn)
A molecule produced by fungi that prevents new blood vessel formation (“angiogenesis”), and may be useful in treating cancers.
References in periodicals archive ?
Successful treatment of disseminated Anncaliia algerae microsporidial infection with combination fumagillin and albendazole.
The research studies conducted in Argentina and Uruguay about nosemosis therapy with Fumagillin clarified that fumagillin treatment should be at least reviewed and that further research should be conducted to acquire a more complete perspective of Nosemosis disease (Giacobino, A.
Gliotoxin and fumagillin: Benzene: ethyl acetate (70:30, v/v).
Kuebler et al., "Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo," Antimicrobial Agents and Chemotherapy, vol.
Other authors reported enhancing effect of theanine, a component of green tea leaves, on the antitumor activity of adriamycin [71], inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 (analog of fumagillin derived from Aspergillus fumigatus) in combination with cisplatin in nude mice [72], and augmented antitumor effects of combination therapy cisplatin/TNP470/IL-12 in melanoma (B6D2F1 mice) and colon carcinoma (Balb/c mice) [73].
Telomerase activity was reduced in MM cell lines in comparison with normal cells by inhibition of MetAP2 (methionine amino-peptidase) with angiostatic agents fumagillin and ovalicin.
Alan Cherrington of Vanderbilt University in Nashville, who has worked on a related drug, fumagillin, said, "Indeed, it would appear that the drug increases the breakdown of fat," though the complete mechanism is not yet known.
Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis.
En la arterioesclerosis, unidos al Fumagillin, podrian reconocer la llegada del farmaco a la placa de ateroma del endotelio mediante resonancia magnetica nuclear y disolverla.
Mersana Therapeutics has entered into a research and exclusive license agreement with Teva Pharmaceutical Industries to develop and commercialize XMT-1107, a novel fumagillin analog for the treatment of all indications, including cancer.
of spores in Fumagillin feces, aspirates topically for (bile, bronchial, keratocon-junctivitis or duodenal), and urine sediments Sarcocystis Direct No known bovihominis detection in treatment.
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent.