FUT2

(redirected from fucosyltransferase 2)

FUT2

A gene on chromosome 19q13.3 that encodes a Golgi membrane protein involved in synthesising an H-antigen precursor, which is required for the final step in synthesising soluble A and B antigens. FUT2 is one of two genes that encode galactoside 2-L-fucosyltransferase.
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Taylor et al., "Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease" Human Molecular Genetics, vol.
Gao, "Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China," World Journal of Gastroenterology, vol.
(75),(76) In particular, group 3 innate lymphoid cells induce the expression of fucosyltransferase 2 on the gut epithelium; this enzyme is a key factor in the regulation of fucosylation of intestinal epithelial cells, the mediators of which include IL-22 and lymphotoxin [alpha].
[6] Human genes: FUT2, fucosyltransferase 2 (secretor status included) (alias, galactoside 2-[alpha]-L-fucosyltransferase 2); FUT3, fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); MGAT5, mannosyl ([alpha]-1,6-)-glycoprotein [beta]-1,6-N-acetyl-glucosaminyltransferase.
Persons carrying [greater than or equal to] 1 functional FUT2 allele, and thus expressing [alpha]1,2 fucosyltransferase 2 (FucT-II), are termed secretor positive (secretors), and can express the A and B blood group antigens as well as H-type 1 and Lewis b ([Le.sup.b]) antigens on mucosa and in secretions.
(2011) Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants.