ALDOA

(redirected from fructose-bisphosphate aldolase A)

ALDOA

A gene on chromosome 16p11.2 that encodes aldolase A (fructose-bisphosphate aldolase), a glycolytic enzyme that catalyses the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is expressed in the developing embryo and in adult muscle, and actively repressed in adult liver, kidney and intestine.

Molecular pathology
Aldolase A deficiency is associated with myopathy and haemolytic anaemia.
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Previous studies have reported that fructose-bisphosphate aldolase A (ALDOA) mRNA increases during in vitro myogenesis (Colbert and Ciejek-Baez, 1988) are responsible for significant activation during the differentiation of primary myoblasts, therefore playing important roles in muscle gene transcription (Walsh et al., 1980; Hidaka et al., 1993; Ren et al., 2011).
Up-regulated proteins are de(ta(3,5)-de!ta(2,4)-dienoyl-CoA isomerase, mitochondrial, platelet-activating factor acetylhydrolase IB subunit beta, endoplasmic reticulum protein ERP29 (ERP29), protea-some subunit beta type-6, fructose-bisphosphate aldolase A, triosephosphate isomerase (TIM), and D-3-phosphoglycerate dehydrogenase (3-PGDH), while down-regulated proteins are TAR DNA-binding protein 43 (TDP-43), splicing factor, arginine/serinerich 1 (SF2/ASF), cDNA FLJ55253 highly similar to actin cytoplasmic 1, eukaryotic translation initiation factor 3 subunit I (eIF3i), and actin aortic smooth muscle.
Fructose-bisphosphate aldolase A and TIM are glycolytic enzymes involving in energy metabolism.