It also catalyzes the reversible rupture of
fructose 1-phosphate into glyceraldehyde and phosphate dihydroxyacetone.
Fructose is converted to
fructose 1-phosphate and then to two metabolites, glyceraldehyde, and dihydroxyacetone phosphate by the enzyme
fructose 1-phosphate aldolase (Figure 7).
In brief, impaired enzyme function allows
fructose 1-phosphate to accumulate, primarily in hepatocytes, kidney cells, and the mucosa of the small intestine.
gal-1-P, glucose 1-phosphate,
fructose 1-phosphate, and fructose 6-phosphate were purchased from Sigma.