It also catalyzes the reversible rupture of fructose 1-phosphate
into glyceraldehyde and phosphate dihydroxyacetone.
Fructose is converted to fructose 1-phosphate
and then to two metabolites, glyceraldehyde, and dihydroxyacetone phosphate by the enzyme fructose 1-phosphate
aldolase (Figure 7).
In brief, impaired enzyme function allows fructose 1-phosphate
to accumulate, primarily in hepatocytes, kidney cells, and the mucosa of the small intestine.
gal-1-P, glucose 1-phosphate, fructose 1-phosphate
, and fructose 6-phosphate were purchased from Sigma.