fructokinase


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fructokinase

 [fruk″to-ki´nās]
an enzyme that catalyzes the transfer of a high-energy phosphate group to d-fructose.

fruc·to·ki·nase

(fruk'tō-kī'nās),
A liver enzyme that catalyzes the reaction of ATP and d-fructose to form fructose 6-phosphate and ADP; deficient in individuals with essential fructosuria (hepatic fructokinase deficiency).

fruc·to·ki·nase

(fruk'tō-kī'nās)
A liver enzyme that catalyzes the reaction of ATP and d-fructose to form fructose 6-phosphate and ADP; deficient in patients with essential fructosuria (hepatic fructokinase deficiency).
References in periodicals archive ?
It is well established that the enzyme fructokinase, would phosphorylate the surplus fructose absorbed from the intestine.
A key player in the process appears to be an enzyme in the liver known as fructokinase, which metabolizes fructose so rapidly that it causes ATP depletion.
Cicerchi et al., "Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver," PLoS ONE, vol.
However, muscle cell does not express fructokinase, and the high value of Km of hexokinase for fructose suggests that this pathway is not critical for fructose metabolism [21].
Perna et al., "Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose," Journal of Nutritional Biochemistry, vol.
The mechanism is not fully understood but it is known that fructose-1-phosphate (a metabolite formed in the liver by fructokinase that phosphorylates quickly fructose, using a molecule of ATP), has the ability to dissociate glucokinase from glucokinase regulatory protein (GKRP).
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology 2013;58:1632-43.
Fructose is metabolized by fructokinase, an enzyme that has two isoforms: fructokinase A and fructokinase C.
The isozyme alcohol dehydrogenase catalyzes in the microorganism the reduction of acetaldehyde to ethanol; however when fructose is not efficiently phosphorylated by fructokinase, both enzymes depend on the sugar in the culture.