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Related to frovatriptan: Frovatriptan succinate


(froe-va-trip-tan) ,


(trade name)


Therapeutic: vascular headache suppressants
Pharmacologic: five ht1 agonists
Pregnancy Category: C


Acute treatment of migraine headache.


Acts as an agonist at specific 5-HT receptor sites in intracranial blood vessels and sensory trigeminal nerves.

Therapeutic effects

Cranial vessel vasoconstriction with associated decrease in release of neuropeptides and resultant decrease in migraine headache.


Absorption: 20–30% following oral administration.
Distribution: Unknown.
Metabolism and Excretion: Mostly metabolized by the liver (P450 1A2 enzyme system); some metabolites eliminated in urine, <10% excreted unchanged.
Half-life: 26 hr.

Time/action profile (blood levels)

POunknown2–4 hrunknown


Contraindicated in: Hypersensitivity;History, symptoms or findings consistent with;Cerebrovascular syndromes including;Uncontrolled hypertension;Hemiplegic or basilar migraine;Peripheral vascular disease, including ischemic bowel disease;Should not be used within 24 hr of any other 5-HT agonist or ergot-type compounds (e.g. dihydroergotamine, ergotamine); Pediatric: Children <18 yr.
Use Cautiously in: Concurrent use of SSRIs or SNRIs (↑ risk of serotonin syndrome); Geriatric: May be more susceptible to adverse cardiovascular effects; Obstetric / Lactation: Safety not established.
Exercise Extreme Caution in: Cardiovascular risk factors (hypertension, hypercholesterolemia, cigarette smoking, obesity, diabetes, strong family history, menopausal women or men >40 yr); use only if cardiovascular status has been evaluated and determined to be safe and first dose is administered under supervision.

Adverse Reactions/Side Effects

Central nervous system

  • dizziness (most frequent)
  • drowsiness
  • fatigue


  • coronary artery vasospasm (life-threatening)
  • mi (life-threatening)
  • ventricular fibrillation (life-threatening)
  • ventricular tachycardia (life-threatening)
  • chest pain
  • myocardial ischemia


  • dry mouth
  • dyspepsia
  • nausea


  • flushing


  • skeletal pain


  • paresthesia


  • pain


Drug-Drug interaction

Hormonal contraceptives or propranolol may ↑ levels.↑ risk of serious vasospastic reactions with dihydroergotamine or ergotamine (concurrent use contraindicated).↑ risk of serotonin syndrome when used with fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram, venlafaxine, or duloxetine.


Oral (Adults) 2.5 mg; if there has been initial relief, a second tablet may be taken after at least 2 hr (daily dose should not exceed 3 tablets and should not be used to treat more than 4 attacks/30 day period).


Tablets: 2.5 mg

Nursing implications

Nursing assessment

  • Assess pain location, intensity, duration, and associated symptoms (photophobia, phonophobia, nausea, vomiting) during migraine attack.

Potential Nursing Diagnoses

Acute pain (Indications)


  • Oral: Tablets may be administered at any time after the headache starts.

Patient/Family Teaching

  • Inform patient that frovatriptan should be used only during a migraine attack. It is meant to be used to relieve migraine attack but not to prevent or reduce the number of attacks.
    • Instruct patient to administer frovatriptan as soon as symptoms appear, but it may be administered any time during an attack. If migraine symptoms return, a second dose may be used. Allow at least 2 hr between doses, and do not use more than 3 tablets in any 24-hr period.
    • If dose does not relieve headache, additional frovatriptan doses are not likely to be effective; notify health care professional.
    • Advise patient that lying down in a darkened room following frovatriptan administration may further help relieve headache.
    • Caution patient not to use frovatriptan if she is pregnant, suspects she is pregnant, plans to become pregnant, or is breast feeding. Adequate contraception should be used during therapy.
    • May cause dizziness or drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
    • Advise patient that overuse (use more than 10 days/month) may lead to exacerbation of headache (migraine-like daily headaches, or as a marked increase in frequency of migraine attacks). May require gradual withdrawal of frovatriptan and treatment of symptoms (transient worsening of headache).
    • Advise patient to notify health care professional prior to next dose of frovatriptan if pain or tightness in the chest occurs during use. If pain is severe or does not subside, notify health care professional immediately. If wheezing; heart throbbing; swelling of eyelids, face, or lips; skin rash; skin lumps; or hives occur, notify health care professional immediately and do not take more frovatriptan without approval of health care professional. If feelings of tingling, heat, flushing, heaviness, pressure, drowsiness, dizziness, tiredness, or sickness develop, discuss with health care professional at next visit.
    • Advise patient to avoid alcohol, which aggravates headaches, during frovatriptan use.

Evaluation/Desired Outcomes

  • Relief of migraine attack.
Drug Guide, © 2015 Farlex and Partners


A triptan-type selective serotonin receptor (5HT1B/1D receptor) agonist (SSRA) used in the acute management of migraine headaches and menstrual migraines.

Vasoconstriction of intracerebral arteries.

Adverse effects
Coronary artery vasospasm, transient myocardial ischaemia or infarction, ventricular tachycardia or fibrillation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A long-acting SEROTONIN agonist drug (see TRIPTANS) used to treat MIGRAINE. A brand name is Migard.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The company said it will now launch its generic Frovatriptan Succinate Tablets 2.5 mg in the US.
Though frovatriptan has the highest activity for [5-HT.sub.1B] receptor (8.2 out of 10) and third highest activity for [5-HT.sub.1D] receptors with the most favourable reoccurrence and adverse drug reaction profile among all the triptans, it is still classified as low efficacy triptan [1].
At the congress, she presented a secondary analysis of data from a published, double-blind, randomized, multicenter crossover trial of frovatriptan (Frova) versus almotriptan (Axert) for the acute treatment of migraine (J.
In a similar trial, frovatriptan (2.5 mg daily or 2.5 mg twice daily), beginning 2 days before the anticipated onset of MM and continuing for 6 days, prevented at least 50% of MM.
SYMPTOM RELIEF (ABORTIVE) Analgesics Aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) Triptans Sumatriptan (Imitrex), zolmitriptan (Zomig), rizatriptan (Maxalt), almotriptan (Axert), and frovatriptan (Frova) Ergot-derivatives Ergotamine (Cafergot, Ercaf, Wigraine), dihydroergotamine (Migranal) PREVENTIVE MEDICINE Blood pressure/cardiac Beta-blockers, calcium channel blockers medications Tricyclic antidepressants Amitriptyline (Elavil), nortriptyline Pamelor) Anti-seizure medications Topiramate (Topamax), divalproex sodium (Depakote)
Vernalis makes frovatriptan, a treatment for migraine that is marketed in Europe and the United States.
It already has a migraine treatment called Frovatriptan.
At least one high-quality randomized controlled trial (RCT) showed a significant reduction in the incidence of MRM when women were treated prophylactically with frovatriptan, a long-acting triptan with a half-life of approximately 26 hours.
M2 EQUITYBITES-April 14, 2014-Mylan announces favourable settlement agreement with Endo Pharmaceuticals for Frovatriptan Succinate Tablets, 2.5 mg
The 48-hour recurrence rate was 15% with frovatriptan, compared with 26% for the other triptans in this recently published pooled analysis (Neurol.
Frovatriptan was also found to be effective for preventing menstrual migraines.