frontotemporal dementia and parkinsonism linked to chromosome 17
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frontotemporal dementia and parkinsonism linked to chromosome 17A rare, autosomal-dominant neurodegenerative disorder (“tauopathy”) with incomplete penetrance, which is characterised by:
(1) behavioural and personality changes,
(2) cognitive impairment, and
(3) motor symptoms.
The phenotype of FTDP-17 varies between families carrying different mutations and within families carrying the same mutation.
(1) clinical features,
(3) molecular genetic analysis.
Symptomatic and supportive.
Extremely poor: lifespan is measured in several months to several years, rarely more.
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