Other reported clinical manifestations are frontal bossing
; sunken cheeks, prominent supraorbital ridges, a saddle nasal bridge and large low set ears.
The first case shows typical characteristics of GHD, in particular, birth growth retardation with growth failure in the first year of life, an absence of psychomotor delay, truncal obesity, and facial dysmorphies such as midface hypoplasia, doll face, and frontal bossing
. An MRI showed only an anterior pituitary hypoplasia, while those for patients with genetic GHD generally reveal a normal or hypoplastic pituitary gland without abnormalities of the hypothalamus, pituitary dystopia, agenesis of the pituitary gland, or thinning or interruption of the pituitary stalk .
Masculine features of the upper third of the face include frontal bossing
, a posteriorly displaced hairline, and heavier, straighter eyebrows.
Congenital anomalies, cleft lip-palate, frontal bossing
, coarse face, hypertelorism 3.
In extra oral examination; colour of skin; frontal bossing
; parietal bossing; hypertelorism; depressed nasal bridge; flaring of alae and maxillary hyperplasia were recorded, while in, intra oral examination: pigmentation, gingivitis.
(2) Frontal bossing
, cleft lip/palate, pectus, and syndactyly of digits.
The phenotypical characteristics pertain to achondroplasia, e.g., frontal bossing
, depressed nasal bridge, short nose because of hypoplasia of nasal bones, and shortened upper and lower extremities are clearly shown in these representations.
The ultrasound also reported anterior narrowing of the skull, short ribs, narrow thorax, increased nuchal translucency, frontal bossing
, short fetal limbs and protuberant abdomen.
Facial features were frontal bossing
, saddle shaped nose, thick everted lips and low set large ears.
If they survive, children with neonatal hyperthyroidism may demonstrate growth retardation, advanced bone age, premature craniosynostosis, exophthalmos, brachydactyly, and frontal bossing
. "It's not a diagnosis you want to miss," Dr.
Clinical examination revealed that patient is short statured (fig1) and presented with brachycephalic skull, frontal bossing
, depressed frontal and parietal bones, hypo plastic maxilla, zygoma & clavicles.