Munkholm LJ, Kay BD (2002) Effect of water regime on aggregate-tensile strength, rupture energy, and friability
. Soil Science Society of America Journal 66, 702-709.
results revealed that the pulverization ratio of MPFs is lower than pure PF and sample MPF2 had the lowest pulverization ratio (1.258%), which indicated considerably decline of 58.29% than that of pure PF.
As expected, compactability and friability
have an inverse relationship.
(%) = Initial weight - Final weight/Initial weight x 100 (1)
The tablet friability
is a method to determine the physical strength of tablets upon exposure to
Some modified release polymers present false negatives with respect to classic tablet hardness and its impact on friability
. In this connection, materials scientists can provide the appropriate test for a tablet made with "non-conventional" excipients.
The prepared tablets were studied for their physical properties like weight variation, hardness, and friability
. For estimating weight variation, 20 tablets of each formulation were weighed using an electronic weighing balance (AW 120, Shimadzu Corporation, Japan).
The prepared liquisolid tablets were evaluated for weight variation, content uniformity, hardness, friability
, and disintegration time.
The floating tablets were evaluated for physicochemical parameters like weight variation, hardness, friability
assay, buoyancy characteristics, swelling studies, in vitro dissolution studies and release mechanism studies.
How does a reasonable person make sense of this?" Tucker asks, striving to answer himself in an almost-over-the-top discussion involving quantum physics, quantum mechanics, the putative friability
of chronology, and the idea of consciousness as a universal "shared dream."
The tablets from each lot of the selected formulation F-C meet up the dosage uniformity requirements of United States Pharmacopoeia, USPXXXI as were found unvarying regarding physical dimensions, percent weight variation, percent friability
, and percent drug contents (Table- 1).