frameshift mutation


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Related to frameshift mutation: point mutation, missense mutation

read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Except these identified SNPs, we identified five novel mutations in the FBN3 gene, including two frameshift mutations (c.
Three novel single base pair deletions resulting in frameshift mutations (c.
However, only approximately 11% of them are frameshift mutations caused by microinsertions.
This study reports the identification of three novel mutations in the apoE gene in a sample of 765 patients with type 2 diabetes, one of which was a novel frameshift mutation.
However, length variations in coding microsatellites (cMS) that produce frameshift mutations inevitably lead to truncated proteins if the respective gene is expressed.
Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin [alpha] chains.
All of the frameshift mutations in TGFBR2 occurred at low frequency, suggesting the presence of MSI subclones in these tumors.
FrxA contained missense alterations in 55 MTZ resistant isolates while the premature truncation of FrxA was caused by frameshift mutations in 9 MTZ resistant strains.
1986; Kronberg & Vartiainen, 1988) and in Salmonella typhimurium TA98, a bacterial strain sensitive to frameshift mutations, MX produces loss or gain of a pair of bases (DeMarini, AbuShakra, Felton, Patterson, & Shelton, 1995).
All are nonsense or frameshift mutations that truncate the profilaggrin molecule.
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome.