frameshift mutation


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Related to frameshift mutation: point mutation, missense mutation

read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.
Synonym(s): addition mutation, addition-deletion mutation, deletion mutation, frameshift mutation

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
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References in periodicals archive ?
Except these identified SNPs, we identified five novel mutations in the FBN3 gene, including two frameshift mutations (c.
Fibrillin 3 Gene Mutation in Chinese Patients with Marfan Syndrome
Three novel single base pair deletions resulting in frameshift mutations (c.
Fanconi anaemia in black South African patients heterozygous for the FANCG c.637-643delTACCGCC founder mutation
However, only approximately 11% of them are frameshift mutations caused by microinsertions.
A Novel Frameshift Mutation in Neurofibromin 1 Gene in a Chinese Family with Neurofibromatosis Type 1
This study reports the identification of three novel mutations in the apoE gene in a sample of 765 patients with type 2 diabetes, one of which was a novel frameshift mutation.
Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus
Genetic sequencing analysis revealed a frameshift mutation (c.
A Novel Mutation of Filamin A Gene in a Chinese Family with Periventricular Nodular Heterotopia
However, length variations in coding microsatellites (cMS) that produce frameshift mutations inevitably lead to truncated proteins if the respective gene is expressed.
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells
Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin [alpha] chains.
Hemoglobin Wayne in a British family: identification by electrospray ionization/mass spectrometry
All of the frameshift mutations in TGFBR2 occurred at low frequency, suggesting the presence of MSI subclones in these tumors.
Clinical actionability enhanced through deep targeted sequencing of solid tumors
FrxA contained missense alterations in 55 MTZ resistant isolates while the premature truncation of FrxA was caused by frameshift mutations in 9 MTZ resistant strains.
CagA status and genetic characterization of metronidazole resistant strains of H. pylori from a region at high risk of gastric cancer
1986; Kronberg & Vartiainen, 1988) and in Salmonella typhimurium TA98, a bacterial strain sensitive to frameshift mutations, MX produces loss or gain of a pair of bases (DeMarini, AbuShakra, Felton, Patterson, & Shelton, 1995).
Mutagenicity and genotoxicity of water treated for human consumption induced by chlorination by-products
All are nonsense or frameshift mutations that truncate the profilaggrin molecule.
Best practices in: pediatric atopic dermatitis
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome.
Late onset central hypoventilation syndrome due to a heterozygous polyalanine repeat expansion mutation in the PHOX2B gene

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