osmotic fragility

(redirected from fragilitas sanguinis)
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fragility

 [frah-jil´ĭ-te]
susceptibility, or lack of resistance, to influences capable of causing disruption of continuity or integrity.
fragility of blood erythrocyte fragility.
capillary fragility abnormal susceptibility of capillary walls to rupture with extravasation.
erythrocyte fragility unusual susceptibility of erythrocytes to hemolysis under certain conditions; see mechanical fragility and osmotic fragility.
mechanical fragility unusual susceptibility of certain erythrocytes to hemolysis under mechanical stress.
osmotic fragility susceptibility of certain erythrocytes to hemolysis when exposed to increasingly hypotonic solutions; seen in some forms of hemolytic anemia and spherocytosis. A test of osmotic fragility is used in diagnosis of some types of hemolytic anemia.

os·mot·ic fra·gil·i·ty

the susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.

osmotic fragility

Red blood cell osmotic fragility test Hematology The susceptibility of RBCs to osmotic lysis; in hypotonic solutions, RBCs behave as perfect osmometers, where the free water rapidly equilibrates, causing the RBCs to swell. See Hereditary spherocytosis.

os·mot·ic fra·gil·i·ty

(oz-mot'ik fră-jil'i-tē)
The susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.
Synonym(s): fragility of the blood.