fragile site


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frag·ile site

[MIM*136540, MIM*136670]
a nonstaining gap at a specific point on a chromosome, usually involving both chromatids, always at the same point on chromosomes of different cells from an individual or kindred; it results in in vitro production of acentric fragments, deleted chromosomes, or other chromosome anomalies; inherited as a dominant chromosome marker.
Farlex Partner Medical Dictionary © Farlex 2012

frag·ile site

(fraj'il sīt)
A nonstaining gap at a specific point on a chromosome, usually involving both chromatids, always at the same point on chromosomes of different cells from an individual or kindred.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

fragile site

a site in a CHROMOSOME where breakage is likely to occur due to the presence of an expanded trinucleotide repeat (see TRINUCLEOTIDE REPEAT EXPANSION DISEASE).
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
FRA3B and other common fragile sites: the weakest links.
Chromosomal fragile sites expressed through an increased frequency in gaps and breaks are identified, as well as a presence of conservation of fragile sites throughout evolution [13, 14].
Cotticelli et al., "The human FHIT gene, spanning the chromosome 3p14.2 fragile site and renal cell carcinoma associated translocation breakpoint, is abnormal in digestive tract cancer,' Cell, vol.
Eleven affected males and one carrier female were found to have a fragile site on the X chromosome (fra(X)(q27)).
The data on AC and NoA was analysed using Mann-Whitney, a non- parametric statistical test (Minitab Statistical Software Release 3.11) to determine variation in the frequency of fragile site expression between different treatments and groups.
The problem is that both copies of a gene can also be frequently deleted from cancers in regions called fragile sites. The underlying DNA structure of fragile sites appears to make them particularly prone to breakage and hence to being jettisoned from the cancer genome.
X-linked mental retardation, macro-orchidism, and the Xq27 fragile site. J Pediatr 1980; 96 : 837-41.
Aberrant Cell Count (AC) and total number of aberrations (NoA) in each animal were used as the measure of fragile site frequency.
Enigma is a fragile site. The harsh desert sun and biting winds are eroding what's left of the remains.
They immediately notified a local archaeologist and a dig was quickly organised on the fragile site.
Although only a small fraction of the wall and its forts has been excavated, the fragile site is being eroded by heavy boots, say archaeologists.
A candidate gene for mild mental handicap at the FRAXE fragile site. Human Molecular Genetics, 5, 275-282.