Three other types of duodenal polyps: mucosal cysts, focal foveolar hyperplasia
, and hyperplastic polyp originating from islands of gastric mucosa.
Drug induced gastritis was defined as absence of polymorphonuclear neutrophils and evident foveolar hyperplasia
Gastric polyps were present in about 10% of patients; these polyps mainly had the histologic characteristics of hyperplastic polyps, with foveolar hyperplasia and markedly proliferating, ectatic capillaries in the lamina propria.
However, typical features of portal hypertensive polyps reportedly include foveolar hyperplasia of the epithelium as well as proliferating, ectatic capillaries in the lamina propria; this indicates their portal hypertensive nature and distinguishes them from inflammatory polyps (Figure 4) [3, 7, 8,11,14].
Duodenal contents reflux through the pylorus into the stomach is a physiological phenomenon that occur in the early morning, postprandial periods, and during endoscopy examination.[sup], Long-term duodenogastric reflux (DGR) can cause pathological conditions such as chronic gastritis, foveolar hyperplasia, intestinal metaplasia, gastric dysplasia, gastric polyp, and gastric cancer.[sup],,,,
pylori infection, foveolar hyperplasia, and dysplasia did not differ significantly among these three groups [Table 1].
Gastric mucosa represented a mature hypersecretory epithelium with erosions, sites of foveolar hyperplasia
, and focal enteric metaplasia of foveolar epithelium.
Histologically the mucosa reveals oedema, foveolar hyperplasia, smooth-muscle proliferation, regeneration and, on occasion, erosion with a relatively mild inflammatory cell response.
A chronic gastritis with marked foveolar hyperplasia, which may be cystic or polypoid, develops proximal to the stoma.
Ungrading NUD (n=133) Foveolar hyperplasia
24 Degenerative changes 65 Lymphoid follicles 20 Gastric atrophy 11 Intestinal metaplasia 15 Dysplasia 0 Parameters PUD (n=36) A.
Reactive gastropathy, the second most common histologic diagnosis made on gastric biopsies, (7) is characterized by foveolar hyperplasia lined by tall columnar cells with variable mucin depletion and enlarged hyperchromatic nuclei.
Foveolar hyperplasia is a response to excessive cell exfoliation from the surface epithelium.