fourth-generation cephalosporin


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fourth-generation cephalosporin

Any of a group of cephalosporin antibiotics possessing broad-spectrum activity They are zwitterions that can penetrate the outer membranes of gram-negative bacteria. Many can cross the blood-brain barrier and are used to treat meningitis.
See also: cephalosporin
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References in periodicals archive ?
The most common initial antibiotics were third-generation cephalosporins in 39% of cases, followed by ampicillin plus a third- or fourth-generation cephalosporin in 16%, and ampicillin plus gentamicin in 11%, with other agents being employed in the low single digits.
The addition of empiric coverage with a third- or fourth-generation cephalosporin for enteric gram-negative bacilli and Pseudomonas aeruginosa may be warranted for severely ill or immunocompromised patients.
The risk of reaction with the newer third-and fourth-generation cephalosporins is extremely low-in the order of 1-2%.