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a broad-spectrum cephalosporin having the greatest activity against gram-negative organisms of any of the cephalosporins. Cefepime is often so classified, although it is sometimes included with the third-generation cephalosporins.
Any of a group of cephalosporin antibiotics possessing broad-spectrum activity They are zwitterions that can penetrate the outer membranes of gram-negative bacteria. Many can cross the blood-brain barrier and are used to treat meningitis.
See also: cephalosporin