Alan showed increased cancer founder cell survival, compromised cell death responses and altered mutation incidence in mice with mutant p53 and mismatch repair pathways.
He pursued the hypothesis that p53 normally drives the death of cells bearing DNA damage and that when p53 is non-functional these cells persist with the potential to become the founder cells of tumours.
These turn the mutated cell into an "early founder cell
of a tumor" (Fey 2004).
Classical experiments performed on gastropod embryos demonstrate that the D macromere plays a critical role in axial patterning as the founder cell
of the dorsal lineage.
Singapore, Singapore, May 30, 2019 --(PR.com)-- In a landmark study, scientists at the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS), Bioprocessing Technology Institute (BTI) and oncologists at the National Cancer Centre Singapore (NCCS), have discovered that cancer stem cells, the founder cells
of a tumour, have unique nutrient requirements.
The discovery of these "kingpin" cells, named human pluripotent founder cells, along with the process of identifying the cells, is expected to open a new channel of research aimed at better understanding the growth of cancerous tumors and how human stem cells make decisions on what to become or not become.
They did, however, find the same subset of founder cells in monkey stem cells.
Role of cell contact in the specification process of pigment founder cells
in the sea urchin embryo.
Clonal contribution maps for molluscs (Render, 1991, 1997; Dictus and Damen, 1997; Henry et al., 2004; Hejnol et al., 2007; earlier studies reviewed by Verdonk and Van den Biggelaar, 1983) have shown that most progeny of the remaining lineage founder cells generate the entire body of the veliger that will not be destroyed at metamorphosis.
Among molluscs however, cell lineage studies on gastropods with different life-history patterns show remarkably little change in fates of cell clones arising from lineage founder cells (Dictus and Damon, 1997; Render 1991.
In addition, cell transplantation studies have indicated that the segmental founder cells
of the leech ('primary blast cells') already possess an intrinsic segment identity several days prior to the onset of Hox gene expression, and will express that original identity - including segment-specific Hox expression - even if their descendant clones are forced to develop in inappropriate segments (9, 11).
A sea urchin homologue of the chordate Brachyury (T) gene is expressed in the secondary mesenchyme founder cells
. Development 121: 2747-2754.