fosphenytoin


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Related to fosphenytoin: Fosphenytoin sodium

fosphenytoin

 [fos´fen-ĭ-toin″]
a prodrug of phenytoin used as the sodium salt in treatment of epilepsy, excluding the petit mal type; administered intravenously or intramuscularly.

fosphenytoin

/fos·phen·y·to·in/ (fos´fen-ĭ-toin″) a prodrug of phenytoin used as the sodium salt in the treatment of epilepsy, excluding petit mal epilepsy.

fosphenytoin

(fŏs′fĕn′ĭ-tō′ĭn, -fə-nĭt′ō-)
n.
A prodrug that is metabolized to phenytoin and administered parenterally for the treatment of seizures.

fosphenytoin

an anticonvulsant.
indications It is used to treat generalized tonic-clonic seizures and status epilepticus.
contraindications Factors that prohibit its use include known hypersensitivity to this drug, psychiatric conditions, pregnancy, bradycardia, sinoatrial and atrioventricular block, and Stokes-Adams syndrome.
adverse effects Life-threatening effects are ventricular fibrillation, nephritis, agranulocytosis, leukopenia, aplastic anemia, thrombocytopenia, megaloblastic anemia, and Stevens-Johnson syndrome. Other adverse effects include drowsiness, dizziness, insomnia, paresthesias, depression, suicidal tendencies, aggression, headache, confusion, hypotension, nystagmus, diplopia, blurred vision, nausea, vomiting, constipation, anorexia, weight loss, hepatitis, jaundice, gingival hyperplasia, urine discoloration, rash, lupus erythematosus, hirsutism, and hypocalcemia.

fosphenytoin

Cerebyx® Neurology A prodrug of phenytoin, which is pharmacologically equivalent to, but causes less phlebitis, soft tissue damage. See Phenytoin, Seizure. Cf Status spilepticus.
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References in periodicals archive ?
The Fosphenytoin Sodium Injection USP, 75 mg/ml, (50 mg PE/ml), which have been packaged in 100 mg PE/2 ml and 500 mg PE/10 ml single-use vials, are generic version of Pfizer's Cerebyx Injection.
Mylan reports generic Cerebyx seizures Injection
The Food and Drug Administration is investigating preliminary data indicating that people with the human leukocyte antigen (HLA) allele HLA-B*1052 may be at greater risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis if they receive phenytoin or fosphenytoin.
Skin reactions seen in Asians on phenytoin
The Food and Drug Administration is investigating preliminary data indicating that people who have the human leukocyte antigen allele HLA-B*1052 may be at a greater risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis during treatment with phenytoin or fosphenytoin.
Asians on phenytoin at high skin reaction risk
The medication behind the question of limits on intramuscular injection volumes is fosphenytoin (Cerebyx[R]).
Administer single-site 30-mL intramuscular injection?
Newer antiepileptic drugs: gabapentin, lamotrigine, felbamate, topiramate and fosphenytoin.
Genetics, genomics and molecular medicine. (Directed Reading)
Fosphenytoin is generally considered safe from cardiac toxicity, and there are no accounts of dysrhythmias in the medical literature.
Section on Emergency Medicine. (Abstracts of Scientific Posters)
These medications include phenobarbital, primidone (Mysoline), phenytoin (Dilantin), carbamazepine (Tegretol), fosphenytoin (Cerebyx), and valproic acid (Depakote).
Watch for Cutaneous Reactions to Lamotrigine. (Anticonvulsant Side Effects can be Fatal)
ampicillin (Polycillin) ciprofloxacin (Cipro) Anticonvulsants: Act on the central nervous ethosuximide (Zarontin) system to reduce number fosphenytoin (Cerebyx) and severity of seizures.
Herb-Medication Interactions: What You Don't Know Can Hurt You
Fosphenytoin (1) and mycophenolate mofetil (MMF) (2) are two examples of prodrugs where monitoring of the active drug, the anticonvulsant phenytoin and the immunosuppressant mycophenolic acid (MPA), respectively, is used to guide therapy.
Prodrug metabolites: implications for therapeutic drug monitoring
New antiepileptics approved in the 1990s include felbamate, gabapentin, lamotrigine, topiramate, tiagabine, and fosphenytoin (Pellock, 1996).
Vigabatrin
Two anticonvulsants, Fosphenytoin and Stedesa have been filed in the US with FDA and 44% of the total anticonvulsants product pipeline is in Phase III clincal studies.
Research and Markets: Anticonvulsants Market to 2016 - Cost Advantage and Dosage Convenience Provided by Generic Anticonvulsants Will Limit Commercial Opportunities for Novel Therapies
Tenders are invited for Inj fosphenytoin 75mg per ml-2ml ampoule
Inj Fosphenytoin 75mg Per Ml-2ml Ampoule

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