KEY WORDS: HIV infection, Herpes zoster, Foscarnet sodium, Interferon.
Foscarnet sodium injection is a well-known, broad- spectrum antiviral agent.
In this study, we compared the clinical effects of foscarnet sodium injection and interferon on HIV- infected patients complicated with herpes zoster.
Foscarnet sodium is a congener of phosphonoacetic acid, and they are both the analogues of pyrophosphates.
Unlike interferon that exerts only short- term effects,16 foscarnet sodium, which is a totally synthesized small molecule compound, functions at the pyrophosphate binding site of viral DNA polymerase.
Herein, the numbers of CD4+ cells and the contents of IL-2 of both groups two and four weeks after treatment significantly exceeded those before treatment (P less than 0.05), with significant inter-group differences also (P less than 0.05), indicating that foscarnet sodium effectively suppressed viral infection and proliferation by regulating immune and inflammatory mechanisms.
Basic and clinical studies also showed that foscarnet sodium was able to well inhibit hepatitis B virus and the activities of T, B lymphocytes.17 In addition, most patients tolerate foscarnet sodium well, without undergoing renal function damages if given enough water therewith.18 In this study, the treatment group scored significantly higher in physical activity, energy, sleep, social life and emotional reaction than the control group did two and four weeks after treatment (P less than 0.05).