forskolin


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for·sko·lin

(fōr'skŏ-lin),
A phorbol ester that binds to and activates protein kinase C, thus mimicking the actions of diacylglycerol.
[fr. Coleus forskohlii, taxonomic name of botanic source]

forskolin (FSK)

an activator of adenylate cyclase. FSK interacts directly with ion channels, increasing glutamate responses and amplitude and decay time of spontaneous excitatory postsynaptic currents.

for·sko·lin

(fōr'skŏ-lin)
A phorbol ester that binds to and activates protein kinase C, thus mimicking the actions of diacylglycerol.
[fr. Coleus forskohlii, taxonomic name of botanic source]
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References in periodicals archive ?
Effects of p,p'-DDT on calcitonin-, human chorionic gonadotropin (hCG)-, and forskolin (FSK)stimulated cAMP production and on inhibition of phosphodiesterase (PDE) by IBMX.
We have employed a human amnion-derived cell line, WISH (Wistar Institute Susan Hayflick), to examine the effect of estradiol-17 [beta] (E2), forskolin (a pharmacological agent which elevates intracellular cAMP), and IL-l[beta] on OXTR mRNA expression.
The common herbal extract forskolin can greatly reduce urinary tract infections and could potentially help antibiotics kill the bacteria that cause most bladder infections.
Nevertheless, past tests had shown that forskolin can rev up production of cyclic AMP, a molecule that's instrumental in producing melanin.
4-[2-[[6-Amino-9-(Nethyl-[beta]-D-ribofuranuronamidosyl)-9H-purin-2- yl]amino]ethyl]benzenepropanoic acid (CGS 21680), 4-(2-[7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-a] [1,3,5]-triazin5-ylamino]-ethyl)phenol (ZM 241385), and forskolin were obtained from Tocris Cookson Ltd.
Addition of cholera toxin (a Gs protein activator), IBMX (a phosphodiesterase inhibitor), or forskolin (an adenylate cyclase activator) likewise suppressed incorporation of [.
Algunas hierbas como la Ginkgo Biloba pueden aumentar la circulacion en el nervio optico, al igual que el forskolin (un extracto de Coleus forskohlii), el cual se ha utilizado como agente topico, para disminuir la presion intraocular.
Halting proliferation by serum starvation or by treatment with forskolin down-regulated these genes.
Keay focusses on developing new synthetic methodology and its application to the synthesis of natural products, as for instance Ambrox, Forskolin and halenaquinone in recent work.