, dexamethasone and VEGF treatments alone, UBC and RPLP0 were used as reference genes.
Efficacy and safety of 1% forskolin
eye drops in open angle glaucoma--An open label study.
The whole experiment was divided into two parts: DOs were cultured in Forskolin
at different concentrations (10 [micro]M, 50 [micro]M, 100 [micro]M) for 3 h, 12 h, or 24 h, then transferred into ordinary culture media for additional period (21 h, 12 h, or 0 h).
On day 28 after spinal cord injury, when PKA were activated by forskolin
the expression of MAP2 was higher in the forskolin
group (1.85 [+ or -] 0.14) (Figure 5(a)) than in the other three groups (P < 0.01, n = 3).
(100 nM and 1 [micro]M) increases the expression of IL-6 significantly (an average around 3.5 and 2.4 fold change compared to vehicle, respectively) (Figure 3, 4a, 4b), a result similar to that of NECA.
Therefore, based on these results, the synergic neuroprotective effect of forskolin
, homotaurine, and L-carnosine has been investigated in a rat model of experimental glaucoma .
and Rp-Cyclic 3',5'-hydrogen phosphorothioate adenosine (Rp-cAMPs), ([alpha]R, [beta]S)-[alpha]-(4-hydroxyphenyl)- [beta]methyl-4-(phenylmethyl)-1-piperidinepropanol maleate (Ro 25-6981) and (9R,10S,12S)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo- 9,12-epoxy-1H-diindolo[1,2,3-fg:3', 2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxyl-icacid, and hexyl ester (KT 5720) were obtained from Tocris.
The adenylate cyclase activators IBMX (0.1 mM) and forskolin
(1 [micro]M) strongly potentiated, by a factor of around 4, glucose-induced insulin secretion (16.7 mM) (Figures 2(a) and 2(b)).
Osborne, "Attivita' neuroprotettiva di una associazione di forskolin
, omotaurina e carnosina su cellule ganglionari retiniche in vitro sottoposte a stress ossidativo," Ottica Fisiopatologia, vol.
Compared to known inducers of pigmentation, IBMX  produced a greater effect on pigmentation than compound 1, whereas forskolin
 produced a lesser effect.
The cells induced to SC-like cells were differentiated, subcultured, seeded on cover slips, and cultured for 4 d in [alpha]-MEM comprising 10% FBS, 5 [micro]M forskolin
, 10 ng/mL bFGF, 5 ng/mL PDGFAA, 200 ng/mL heregulin1-[beta]1, and 10 ng/mL NT3; then, immunofluorescence analysis was performed.
has the ability to activate the adenylate cyclase enzyme without interacting with cell surface receptors, (44,45) which consequently increases the formation of intracellular cyclic adenosine monophosphate (cAMP).