ADH5

(redirected from formaldehyde dehydrogenase)

ADH5

A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH5 has minimal activity for ethanol oxidation, but has a high activity for oxidation of long-chain aliphatic alcohols and oxidation of S-(hydroxymethyl) glutathione. The ADH5 protein product is critical in metabolic elimination of formaldehyde, a potent irritant and sensitising agent that causes lacrymation, rhinitis, pharyngitis and contact dermatitis.
References in periodicals archive ?
5 min), is metabolized into formic acid in the liver and erythrocytes, with a reaction catalyzed by formaldehyde dehydrogenase (FDH) enzymes after FA is taken into body, regardless of the manner (respiratory, oral, i.
The product of the ubiquitously expressed ADH5 gene is the glutathione-dependent formaldehyde dehydrogenase (also known as nitrosoglutathione reductase [GSNOR]).
Mutation of Arg-115 of human class III alcohol dehydrogenase: A binding site required for formaldehyde dehydrogenase activity and fatty acid activation.
Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase.
formaldehyde dehydrogenase and formaldehyde dismutase, which can oxidize formaldehyde to non-toxic compounds (Ando et al.
Based on the genomic information at NCBI, a gene-encoding formaldehyde dehydrogenase (fdhA) does exist in A.
Function of a glutathione-dependent formaldehyde dehydrogenase in Rhodobacter sphaeroides formaldehyde oxidation and assimilation.
Cloning and high-level expression of the glutathione-independent formaldehyde dehydrogenase gene from Pseudomonas putida.
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