FOXP1(redirected from fork-head box)
FOXP1(1) A transcription-factor protein encoded by FOXP1 on chromosome 3p14.1, which belongs to subfamily P of the fork-head box transcription-factor family. It has DNA- and protein-binding domains, and plays an important role in cell transformation, differentiation and proliferation.
FOXP1 is widely expressed in normal tissues, and has a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium.
Loss of nuclear FOXP1 expression or mislocation in cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma.
(2) A gene on chromosome 3p14.1 which encodes a winged-helix transcription-factor (FOXP1) in the fork-head box family, which has a key role in cell transformation, differentiation and proliferation.
FOXP1 overexpression is associated with a lower disease-free survival in diffuse, large B-cell lymphoma.