ACVR1

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ACVR1

A gene on chromosome 2q23-q24 that encodes activin receptor type I, a receptor that forms a complex with other type-I and two type-II transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate, then bind and activate SMAD transcriptional regulators, playing roles in cell differentiation, growth arrest and apoptosis. 

Molecular pathology
ACVR1 mutations are linked to fibrodysplasia ossificans progressive.
References in periodicals archive ?
The FOP report concluded "officers followed direct orders from command staff not to intervene or engage the rioters" in April 2015 when peaceful protests escalated.
Mean agreement for the SOP, MOP, and FOP conditions was 100%, 100%, and 98.6% (range of 83%100%), respectively.
This finding "promotes our understanding of FOP but also, at the same time, provides us with candidates for therapeutic drugs.
In February 2016, the Standing Senate Committee on Social Affairs, Science and Technology called for stricter nutrition labelling regulations, including mandating the use of FOP labelling on foods required to display an NFt.
Originally, the researchers wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation.
Founded in 1948, the New Jersey State Lodge of the FOP has over 16,000 members, one of the largest FOP state lodges in America.
The NSSF has honored the nation's fallen law enforcement officers by contributing $25,000 to the Fraternal Order of Police (FOP) Foundation.
PESHAWAR -- Paraplegic Centre and Friends of Paraplegics (FOP) here Monday organized a walk demanding observance of world day to create public awareness regarding various spinal cord injuries.
Products that show front-of-pack (FOP) nutrition symbols may not be any healthier than those without them, according to researchers.