follicular hyperplasia

follicular hyperplasia

A reactive pattern seen in benign lymphadenopathy that consists of idiopathic expansion of lymphoid follicles (germinal centres containing centroblasts, centrocytes and follicular dendritic cells), which is seen in lymph nodes with chronic nonspecific lymphadenitis.
 
Aetiology
Infections that evoke B-cell response (e.g., HIV), SLE, toxoplasmosis, leishmaniasis, syphilis, adult-onset Still’s disease, Felty syndrome.

DiffDx
Follicular hyperplasia is normal in children, but may also occur in Castleman’s angiofollicular hyperplasia, follicular lymphoma, lymphocyte predominant Hodgkin lymphoma, progressive transformation of germinal centres.
References in periodicals archive ?
Thyroid follicular hyperplasia was histologically observed in all birds examined, while granulomatous thyroiditis and microfollicular adenoma were observed in 2 birds, respectively.
In addition, the surrounding lymphoid tissue showed against the background of what appeared to be preceding follicular hyperplasia features of marked folliculolysis, and increased plasmacytoid cells and plasma cells were also seen populating some of the follicles.
The enlarged mesenteric lymph nodes demonstrated reactive follicular hyperplasia and multifocal non-necrotizing lipogranulomas.
Reactive lymphoid follicular hyperplasia, infectious mononucleosis, and nasopharyngeal carcinoma (nonkeratinizing type) need to be excluded histologically and/or immunophenotypically.
Histopathologically, enlarged lymph nodes usually showed a reactive follicular hyperplasia.
WORK-UP: The patient's past medical history revealed numerous infectious and immunologic problems, including mild varicella as a preschooler, follicular hyperplasia, adenoidal hypertrophy, splenomegaly, a goiter and hypothyroidism associated with Hashimoto's thyroiditis, multiple episodes of otitis media necessitating several myringotomies, and infectious mononucleosis.
The tonsil had severe multifocal coalescing areas of caseous necrosis and heterophilic inflammation with reactive lymphoid follicular hyperplasia.
This article will focus on 2 of the most commonly encountered changes, both of which have a follicular/nodular pattern: follicular hyperplasia and progressive transformation of germinal centers (PTGC), and the lymphomas that resemble them.
The proliferative phase shows follicular hyperplasia and paracortical expansion with scattered apoptoses.
Occasionally, this finding may be accompanied by other prominent reactive morphologic features, including florid follicular hyperplasia or dermatopathic change.
Histopathology of tonsil showed follicular hyperplasia interspersed with immature cartilage and bone cells.

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