follicular hyperplasia

follicular hyperplasia

A reactive pattern seen in benign lymphadenopathy that consists of idiopathic expansion of lymphoid follicles (germinal centres containing centroblasts, centrocytes and follicular dendritic cells), which is seen in lymph nodes with chronic nonspecific lymphadenitis.
 
Aetiology
Infections that evoke B-cell response (e.g., HIV), SLE, toxoplasmosis, leishmaniasis, syphilis, adult-onset Still’s disease, Felty syndrome.

DiffDx
Follicular hyperplasia is normal in children, but may also occur in Castleman’s angiofollicular hyperplasia, follicular lymphoma, lymphocyte predominant Hodgkin lymphoma, progressive transformation of germinal centres.
References in periodicals archive ?
Duodenal-type FL, because of its histologic low grade and indolent behavior, can be confused with several different lymphoid entities, such as reactive follicular hyperplasia, MALT lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, and GI involvement by systemic FL.
A heterogeneous distribution and a polymorphic lymphocytic population, with cellular aggregates representative of germinal centers, usually point toward nonspecific reactive follicular hyperplasia. Nevertheless, reactive hyperplasia is typically marked by a predominance of large cells and immunoblasts, sometimes even with atypical forms (common in clinical conditions associated with viral infections, such as infectious mononucleosis).
The aim of this study was to evaluate VEGF-A expression and MVD through expression of CD31 in endothelial cells in aggressive lymphomas such as DLBCL, in indolent lymphomas such as FL, and in lymph node reactive follicular hyperplasia (FH).
Histopathological examination of the skin was consistent with neutrophilic urticaria (Figure 2a) and lymph nodes showed follicular hyperplasia and polytypic plasmacytosis (Figure 2b) with polyclonality to IgH/K/L genes.
The difference was compared between two groups, including age, gender, conjunctival and corneal fluorescein staining, TBUT, Schirmer I test, conjunctival congestion, papillary and follicular hyperplasia, secretions, corneal nerve fibers and the number of local lymphocyte, and dry eye severity (dry eye grading).
Lymph nodes showed reactive follicular hyperplasia, sinus histiocytosis, and scattered nonnecrotizing granulomas (Figure 2).
Although the pathogenesis of PTGC is unclear and likely multifactorial, it is believed to be a state of follicular hyperplasia following reactive stimuli [5, 6].
A second examination in another laboratory by an expert led to the conclusion that it was a follicular hyperplasia with an atrophic germinal center, with polytypic plasma cells in the interfollicular area; these results suggested that it might be a plasma cell variant of Castleman disease.
Thyroid follicular hyperplasia was histologically observed in all birds examined, while granulomatous thyroiditis and microfollicular adenoma were observed in 2 birds, respectively.
Rough hypoplasticamelogenesisimperfecta with follicular hyperplasia. Oral Surg Oral Med Oral Pathol 1992; 74: 87-92.
In addition, the surrounding lymphoid tissue showed against the background of what appeared to be preceding follicular hyperplasia features of marked folliculolysis, and increased plasmacytoid cells and plasma cells were also seen populating some of the follicles.
However, for the patient reported here, persistence of inguinal swelling prompted a repeat biopsy 4 months later; the specimen again demonstrated reactive follicular hyperplasia, although no parasites were seen.

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