The goal of the present study was to determine if varying
folate intake modifies iAs metabolism and metabolic phenotype in wild-type (WT) male and female C57BL/6J mice exposed to iAs in drinking water (100 ppb), with and without a high-fat diet (HFD) as an additional metabolic stressor.
This partnership with Merck KGaA will allow for a broader application of ITM's Theranostics platform to include diagnosis and therapy of patients with
folate receptor-positive cancers.
Naturally occurring
folates exist in many chemical forms;
folates are found in food, as well as in metabolically active forms in the human body.
Tomar rightly concluded, "A number of studies have shown that high intakes of folic acid, the chemically synthesized form, but not natural
folates, can cause adverse effects in some individuals such as the masking of the hematological manifestations of vitamin B12 deficiency, leukemia, arthritis, bowel cancer, and ectopic pregnancies." (22) They also concluded that food forms were preferred for pregnant women.
DSM, Parsippany, NJ, has partnered with Merck, Whitehouse Station, NJ, to distribute and market its L-MTITF Metafolin
folate to the dietary supplement and food industries.
Kimmins said that fathers who eat high-fat, fast food diets or who are obese may not be able to use or metabolize
folate in the same way as those with adequate levels of the vitamin.
STRONG EVIDENCE EXISTS THAT VITAMIN [B.sub.9], known as
folate in its natural form and folic acid in its synthetic form--in adequate quantities and at appropriate timing--can reduce the risk for neural tube defects (NTDs).
Since folic acid fortification has become mandatory, the incidence of neural tube defects (NTDs) has declined in Canada by approximately 50%, (4) with improvements in blood
folate indices (5,6) and
folate intake.
Folate concentration in serum and erythrocytes is a marker of
folate status, which is inversely associated with the plasma concentration of total homocysteine (tHcy).
Folate concentrations were quantified using reversed-phase high-performance liquid chromatography, and degradation products were identified using the same technique.
Natural
folates occur predominantly as polyglutamylated molecules with a short [gamma]-linked chain of glutamyl residues attached to the first glutamate.
Objective.--To determine the rate of
folate deficiency in a cohort of indigent patients, a population among those at highest risk for
folate deficiency.
