focal segmental glomerulosclerosis


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Related to focal segmental glomerulosclerosis: Minimal change disease, membranoproliferative glomerulonephritis

glomerulosclerosis

 [glo-mer″u-lo-sklĕ-ro´sis]
diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.
focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

fo·cal seg·men·tal glo·mer·u·lo·scle·ro·sis

(fō'kăl seg-men'tăl glo-mer'yū-lō-skler-ō'sis)
Segmental collapse of glomerular capillaries with thickened basement membranes and increased mesangial matrix; seen in some glomeruli of patients with nephrotic syndrome or mesangial proliferative glomerulonephritis.

focal segmental glomerulosclerosis

An irreversible form of glomerular injury often seen in patients with a history of injection drug use or acquired immunodeficiency syndrome.
References in periodicals archive ?
Buchler et al., "Rituximab for recurrence of primary focal segmental glomerulosclerosis after kidney transplantation: Clinical outcomes," Transplantation, vol.
Selgas, "Inhibition of tyrosine kinases by sunitinib associated with focal segmental glomerulosclerosis lesion in addition to thrombotic microangiopathy," Nephrology, Dialysis, Transplantation, vol.
Focal segmental glomerulosclerosis was the leading histopathological cause of primary renal disease.
Abbreviations GFR: Glomerular filtration rate MGN: Membranous glomerulonephritis FSGS: Focal segmental glomerulosclerosis Hb: Hemoglobin ATN: Acute tubal necrosis DMARDs: Disease modifying antirheumatic drugs TNF-[alpha]: Tumor necrosis factor-[alpha] MDRD: Modification of diet in renal disease.
Lewis," Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants," Journal of the American Society of Nephrology, vol.
Though the renal histology of most patients with steroid sensitive nephrotic syndrome (90%) reveals minimal change nephropathy (MCN), the renal histology in SRNS is different, with up to 30-40% of patients showing focal segmental glomerulosclerosis (FSGS) [4].
Phase II Ligand Pharmaceuticals' partner Retrophin, achieved positive results from the Phase II DUET study of sparsentan for the treatment of focal segmental glomerulosclerosis (FSGS), a rare kidney disorder that often leads to end-stage renal disease.
Cole, who had a brief loan spell at Blues in 2007, as he wound down a glittering career best known for his glory years at Manchester United, is suffering from focal segmental glomerulosclerosis (FSGS).
Primary focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome and leads to end-stage renal disease in approximately 40% of cases.
M2 EQUITYBITES-November 17, 2015-Retrophin wins orphan drug designation for sparsentan for focal segmental glomerulosclerosis in Europe
He has been diagnosed with focal segmental glomerulosclerosis and, in a statement on Twitter, Cole, 44, told fans that he contracted an airborne virus in June and suffered kidney failure.
He has been diagnosed with focal segmental glomerulosclerosis and said a course of strong steroids has led to a recent change in his appearance.

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