focal nodular hyperplasia
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abnormal increase in volume of a tissue or organ caused by the formation and growth of new normal cells. See also hypertrophy and proliferation. adj., adj hyperplas´tic.
benign prostatic hyperplasia benign prostatic hypertrophy.
cutaneous lymphoid hyperplasia a group of benign cutaneous disorders characterized by accumulations of large numbers of lymphocytes and histiocytes in the skin, which may occur as a reaction to insect bites, allergy hyposensitization injections, light, trauma, or a tattoo pigment or may be of unknown etiology.
focal nodular hyperplasia (FNH) a benign, usually asymptomatic tumor of the liver, occurring chiefly in women; it is a firm, nodular, highly vascular mass resembling cirrhosis, usually with a stellate fibrous core containing numerous small bile ducts, and having vessels lined by Kupffer cells.
nodular hyperplasia of the prostate benign prostatic hypertrophy.
focal nodular hyperplasiaA relatively common (±1% of general population) benign lesion that develops spontaneously at age 20–30, predominantly in females, and not associated with oral contraceptives. If multiple (1/3 are multiple), it may be associated with vascular defects in other organs and brain (arteriovenous malformations).
Focal nodular hyperplasia
• Congenital arterial malformation.
• Acquired vascular abnormalities;
• Other neoplasms;
• Venous thrombosis.
• Cirrhosis-like changes;
• Chronic biliary disease with bile duct loss;
• Adjacent space-occupying lesion.
• Large cell atypia;
• Mixed hyperplastic and adenomatous;
• No central scar, especially in lesions < 1cm;
• No prominent ductular reaction;
Generally asymptomatic; larger lesions may undergo infarction.
Nodular lesion with central scar.
Generally conservative management; indications for surgery uncertain.