To determine whether teneligliptin regulated
foam cell formation in macrophages ex vivo, we assessed the effect of teneligliptin on ox-LDL-induced
foam cell formation in the peritoneal macrophages of the diabetic db/db mice and monocyte-derived macrophages differentiated by 7-day culture isolated from the T2D patients.
Lipid accumulation in monocytes and macrophages is responsible for differentiation of these cells into
foam cells and represents a key step in the development of atherosclerosis [5, 28].
Liu et al., "Salusin-beta induces
foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFkappaB pathway," Scientific Reports, vol.
XGP shows specific findings of large, clear
foam cells. The rapid diagnosis of frozen pathological sections has been attempted in previous studies; however,
foam cells appear similar to the cells in renal clear cell carcinoma; thus, a differential diagnosis was found to be difficult.
Lu et al., "Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in
foam cells by a water-soluble fraction of Polygonum multiflorum," Journal of Pharmacological Sciences, vol.
After the intervention of 12 days, [sup.3]H-cholesterol-labeled macrophage
foam cells were intraperitoneally injected into C57BL/6J mice.
Lectin histochemistry of
foam cells in tissues of cattle grazing Brachiaria spp.
Nanoparticles aimed at reducing inflammation associated with atherosclerosis target macrophages and related
foam cells, the immune players that congregate at plaques.
Darapladib was beneficial in lowering the levels of Ox-LDL, lipid profiles (LDL), and numbers of
foam cells. Darapladib was also beneficial in increasing the level of HDL (repeated ANOVA, p < 0.05).
Targeting of macrophage
foam cells in atherosclerotic plaque using oligonucleotide-functionalized nanoparticles.
In aorta of animals of group B, H and E stained slides displayed that in addition to intracellular lipid accumulation in
foam cells present mostly in intima, pools of extra cellular lipids were also visible in deeper layers.
Half of cases show necrotizing pattern and the xanthomatous type is rare and has abundant
foam cells. (6) Cellular protein structures have been noted in the cytoplasm of lymphocytes and histiocytes that have also been found in those cells of patients with SLE.
