No standardization of the use of adjunctive chemotherapy or regimens have been agreed upon, but agents reported include cisplatin, gemcitabine, 5-FU, mitomycin, adriamycin, thiotepa, fluoxymesterone
, carboplatin, paclitaxel, docetaxel, and VP-16 [1, 4, 7,14].
In July, the company announced that it had received Food and Drug Administration approval for a supplemental Abbreviated New Drug Application and request for an alternate active pharmaceutical ingredient (API) manufacturer for Androxy (Fluoxymesterone
Tablets), which treats a lack of natural testosterone in men and advanced breast cancer in post-menopausal women.
Exogenous: 1-androstendiol, 1-androstendione, bolandiol, bolasterone, boldenone, boldione, calusterone, clostebol, danazol, dehydrochlormethyltestosterone, desoxymethyltestosterone, drostanolone, ethylestrenol, fluoxymesterone
, formebolone, furazabol, gestrinone, 4-hydroxytestosterone, mestanolone, mesterolone, metenolone, methandienone, methandriol, methasterone, methyldienolone, methyl-1-testosterone, methylnortestosterone, methyltrienolone, methyltestosterone, mibolerone, nandrolone, 19-norandrostenedione, norboletone, norclostebol, norethandrolone, oxabolone, oxandrolone, oxymesterone, oxymetholone, prostanozol, quinbolone, tanozolol, stenbolone, 1-testosterone, tetrahydrogestrinone, trenbolone
The first evidence linking CYP2D6 variants with treatment response was obtained from a prospective randomized phase III trial of postmenopausal women with ER-positive breast cancer (North Central Cancer Treatment Group adjuvant breast cancer trial) for the investigation of the effect of adding the androgen fluoxymesterone
for 1 year to the standard regimen of 5 years of adjuvant tamoxifen.