Besides, the practical application of perftorans is accompanied by a number of medical problems: infusion of perfluorocarbon Fluosol-DA can cause anaphylactic reaction (Watanabe et al., 1988).
"Experimental study on anaphylactic effects by Fluosol-DA," Jpn.
More on the performance of the IL282 CO-oximeter in the presence of perfluorochemical emulsion, Fluosol-DA
That led to the development of a product called Fluosol-DA, a synthetic, acellular oxygen carrier made from two fluorine-containing (per-fluorocarbon) compounds and--among other things--an egg yolk constituent and a mild detergent.
The researchers concluded that Fluosol-DA was "unnecessary in moderate anemia and ineffective in severe anemia.'
As if these internal threats weren't enough, the appearance of artificial or genetically produced blood substitutes further complicates the marketplace for blood banking.3 The red cell substitute Fluosol-DA
, discovered by the Japanese, is undergoing clinical trials on humans.
Role of the perfluorocarbon Fluosol-DA in coronary angioplasty.
The preoperative treatment of severely anemic patients with a perfluorochemical oxygen-transport fluid, Fluosol-DA. N Engl J Med 1982; 307:277-83.
[O.sub.2] and C[O.sub.2] solubility of the fluorcarbon emulsion Fluosol-DA 20% and [O.sub.2] and C[O.sub.2] dissociates curves of blood Fluosol-DA 20% mixtures.
, first developed in Japan, is a patented emulsion of two such perfluorochemical compounds, perfluorodecalin and perfluorotripropylamine.