Lantheus Holdings announced "positive" new data from a Phase 2 study of LMI 1195, a fluorine-18 labeled tracer for use in cardiac positron emission tomography to assess myocardial presynaptic sympathetic nerve function.
Most of the new products that are expected to reach the market by 2024-2026 will be labelled with Fluorine-18, Gallium-68 or Technetium-99m for the radiodiagnostics and with Lutetium-177 and Iodine-131 for the radiotherapeutic products.
NAV4694 is a Fluorine-18 labeled precision radiopharmaceutical candidate intended for use in Positron Emission Tomography imaging and evaluation of patients with signs or symptoms of cognitive impairment such as Alzheimer's disease.
Australian Certified Reference Materials (ACRMs) for radionuclides such as Fluorine-18 (F-18) cant be transported long distances because they have such short half-lives, so we need to be able to produce them onsite at the cyclotrons, said Bonnie Howe (pictured above), a radionuclide metrologist at ANSTO.
BFPET, which is entering Phase II studies in the US, is a marker of mitochondrial membrane integrity and can be used to evaluate myocardial perfusion with all the potential benefits of Fluorine-18 PET imaging, such as higher image resolution fewer image artifacts.
One of these modalities, fluorine-18 fluorodeoxyglucose-positron-emission tomography/computed tomography (FDG-PET/CT), has become very important in the detection of malignancies because it provides functional and metabolic information as well as anatomic localization.