Laboratory test results were negative for rapid plasma reagin, fluorescent treponemal antibody absorption
, tuberculosis (Quantiferon-Gold TB; Quest Diagnostics, https://www.questdiagnostics.com), angiotensin-converting enzyme, rheumatoid factor, antinuclear antibody, and human leukocyte antigen B27.
pallidum enzyme-linked immunosorbent assay (TP-EIA), fluorescent treponemal antibody absorption
(FTA-ABS) test, or T.
pallidum and include fluorescent Treponemal antibody absorption
pallidum, the etiological agent of syphilis, produces at least two types of antibodies in human infections: treponemal antibodies that can be detected by fluorescent treponemal antibody absorption
(FTA-ABS) and nontreponemal antibody (reagin) that can be detected by RPR antigen card or VDRL test.
Diagnosis is confirmed with specific treponemal testing, such as with a fluorescent treponemal antibody absorption
assay or the T pallidum particle agglutination test.
Yes 170 8.9 No 1213 63.7 Do not know 522 27.4 Total 1905 100 Abbreviations: CLIA, Clinical Laboratory Improvement Amendments; CMIA, chemiluminescent microplate immunoassay;EIA, enzyme immunoassay; FTA-ABS, fluorescent treponemal antibody absorption
test;TP-LIA, Treponema pallidum line immunoassay;MHA-TP, micro-hemagglutination assay for Treponema pallidum antibodies;PK-TP, Olympus automated hemagglutination test;RPR, rapid plasma reagin assay; TP-PA, Treponema pallidum particle agglutination assay; VDRL, venereal disease research laboratory test;USR, unheated serum reagin test.
He tested positive for HIV using serum enzyme linked immunosorbent assay (ELISA), rapid plasma reagin was 1:128 (reference range, nonreactive), fluorescent treponemal antibody absorption
test was reactive (reference range, nonreactive) and neurosyphilis was ruled out with negative spinal fluid studies.
FTA-ABS (fluorescent treponemal antibody absorption
Treponemal tests: Treponemal tests, including the FIA-Abs (fluorescent treponemal antibody absorption
) test and syphilis immunoassays, detect antitreponemal antibodies and indicate exposure to syphilis during the patient's lifetime.(1-3) A positive result, however, does not mean the patient currently has untreated syphilis.
Laboratory testing conducted during the initial evaluation 79 days before transplant showed no evidence of infection with HIV by EIA, hepatitis B virus (HBV) by HBV surface antigen testing, or hepatitis C virus (HCV) by anti-HCV serology; a rapid plasma reagin test for syphilis was reactive undiluted (1:1) with a fluorescent treponemal antibody absorption
test, also positive, consistent with previously treated syphilis.
Laboratory tests revealed that his erythrocyte sedimentation rate (ESR), antinuclear antibody (ANA) level, rheumatoid factor (RF) value, and fluorescent treponemal antibody absorption
(FTA-ABS) titers were within normal limits.
These tests represent advances over the tests used now, the rapid plasma reagin and fluorescent treponemal antibody absorption
tests, observed Penelope Hitchcock, D.V.M., chief of the STD branch at the National Institute of Allergy and Infectious Diseases, Bethesda, Md.