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a steroid antiinflammatory agent administered as an aerosol spray for treatment of bronchial asthma and seasonal or perennial allergic rhinitis when conventional treatment is unsatisfactory.


APO-Flunisolide (CA), Nasarel, PMS-Flunisolide (CA), Ratio-Flunisolide (CA), Rhinalar Nasal Mist (CA)

Pharmacologic class: Intranasal steroid

Therapeutic class: Respiratory inhalant

Pregnancy risk category C


Unknown. Thought to diminish capillary permeability and suppress migration of polymorphonuclear leukocytes, decreasing inflammation.


Spray solution: 25 ml (each actuation delivers approximately 25 mcg)

Indications and dosages

Relief of seasonal or perennial rhinitis

Adults: Two sprays in each nostril b.i.d.; may increase to two sprays in each nostril t.i.d. Maximum daily dose is eight sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.

Children ages 6 to 14: One spray in each nostril t.i.d. or two sprays in each nostril b.i.d.; maximum daily dose is four sprays in each nostril. For maintenance, after desired clinical effect occurs, reduce dosage to smallest amount needed to control symptoms.


• Hypersensitivity to drug or its components

• Untreated local infections of nasal mucosa


Use cautiously in:

• localized Candida albicans infection; tuberculosis; untreated fungal, bacterial, or systemic viral infections; ocular herpes simplex

• patients receiving immunosuppressive therapy.


• Don't increase dosage or discontinue drug abruptly.

Adverse reactions

CNS: headache, light-headedness, nervousness, dizziness

EENT: cataracts; glaucoma; blurred vision; conjunctivitis; increased intraocular pressure; lacrimation; dry, irritated eyes; tinnitus; otitis; otitis media; rhinorrhea; rhinitis; nasal irritation, burning, and dryness; nasal stuffiness and pain; sneezing; nasal ulcer; epistaxis; localized Candida albicans nasal infections; nasal mucosa ulcerations; nasal septum perforation; throat discomfort, soreness, and dryness; mild nasopharyngeal irritation; pharyngitis; dry mucous membranes; nasal and sinus congestion; sinusitis; hoarseness, voice changes

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth

Metabolic: hyperadrenocorticism

Musculoskeletal: myalgia, arthralgia, aseptic necrosis of femoral head

Respiratory: wheezing, dyspnea, increased cough, bronchitis, bronchospasm, asthma symptoms

Skin: rash, pruritus, urticaria, contact dermatitis, alopecia, herpes simplex infection

Other: altered taste and smell, facial edema, fever, flulike symptoms, aches and pains, infections, angioedema, anaphylaxis


Drug-diagnostic tests. Aspartate aminotransferase: increased level

Patient monitoring

Monitor patient closely for serious adverse reactions, including anaphylaxis, angioedema, hyperadrenocorticism, and serious infections.

Patient teaching

Teach patient to recognize and immediately report serious adverse reactions.

• Teach patient proper use of drug. Caution him not to use more than prescribed amount; doing so may cause serious side effects.

• Tell patient maximum drug effects may not occur for several weeks.

• Tell patient to avoid people with measles, chickenpox, and other transmissible infections.

• Caution patient to withhold dose and contact prescriber if infection occurs.

• Instruct female patient to tell prescriber if she becomes pregnant.

• Tell female patient not to breastfeed without consulting prescriber.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.


/flu·nis·o·lide/ (floo-nis´o-līd″) a synthetic glucocorticoid used as the acetate salt in treatment of bronchial asthma and seasonal and nonseasonal allergic rhinitis.


A corticosteroid, C24H31FO6, administered by inhalation to treat asthma and nasally to treat allergies.


an intranasal and oral inhalation adrenal corticosteroid.
indications It is prescribed in the treatment of seasonal or continuing allergic rhinitis that involves inflammation of the mucous membranes of the nasal passages and for the treatment of asthma.
contraindications It should not be given to patients with allergy to this drug or any of its components or to patients with status asthmaticus or untreated bacterial, viral, or fungal infections of the respiratory tract or nasal mucosa.
adverse effects The side effects most often reported include nasal or throat irritation, stinging, burning, or dryness; nosebleed; sneezing; bloody mucus; congestion; asthma; increased coughing; sore throat; or lesions in the nose or throat.


Aerobid® An inhalant corticosteroid used to manage asthma


A CORTICOSTEROID drug used in the form of a spray to treat hay fever. A brand name is Syntaris.
References in periodicals archive ?
These trials tested different doses of all drugs except triamcinolone and flunisolide.
In contrast, 56% of beclomethasone HFA and 68% of flunisolide HFA particles are deposited in the lung.
triamcinolone acetonide (Azmacort[R]), flunisolide (Aerobid[R]):
Beclomethasone, budesonide, triamcinolone, and flunisolide are the inhaled corticosteroids most commonly used for asthma control.
Beclomethasone dipropionate, betamethasone, budesonide, dexamethasone, fludrocortisone, flunisolide, fluorometholone, megestrol acetate, methylprednisolone, prednisolone, prednisone, triamcinolone, and triamcinolone acetonide were purchased from Sigma.
24 (Pulmicort) [micro]g/day (400 [micro]g) (*) flunisolide 500-1,000 $2.
She was controlled on theophylline, inhaled serevent, flunisolide, nedocromil, oral antihistamines, and regular peak flow monitoring.
34] Other topical steroids include beclomethasone, flunisolide, mometasone, and triamci nolone.
Most anti-inflammatory agents used to treat asthma are corticosteroids including prednisone, beclomethasone, triamcinolone, dexamethasone, and flunisolide.
Asthma Long-Term-Control Medications Generic name Brand name Steroids: Inhaled beclomethasone Beclovent(*) Vanceril(*), Vanceril(*)--Double Strength budesonide Pulmicort Turbuhaler(*) flunisolide AeroBid(*), AeroBid-M(*) fluticasone Flovent(*) triamcinolone Azmacort(*) Cromolyn and Nedocromil: Inhaled cromolyn sodium Intal(*) nedocromil sodium Tilade(*) Leukotriene Modifiers: Tablets zafirlukast Accolate(*) zileuton Zyflo(*) Long-Acting [Beta.
A single inhalation of flunisolide contains about 250 micrograms of the drug--and six inhalations per day would be required to reach this level.