floxuridine


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floxuridine

 [floks-ūr´ĭ-dēn]
an antimetabolite, derived from fluorouracil and used as an antineoplastic agent by intra-arterial administration for treatment of liver metastases from gastrointestinal malignancies.

floxuridine

Oncology An antimetabolic fluoropyrimidine, a metabolite of 5-FU. See 5-Fluorouracil.
References in periodicals archive ?
Wieand et al., "Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer.
1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine -- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.
(35) Primary sclerosing cholangitis-like injury is a relatively uncommon pattern that is mainly seen with infusion of chemotherapy agents into the hepatic artery such as floxuridine and fluorouracil to treat metastatic colorectal cancer to the liver, as well as hepatic arterial chemoembolization in hepatocellular carcinoma.
The same group developed irinotecan: floxuridine liposomes (CPX-1, 1: 1 molar ratio).