floxuridine

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floxuridine

[floks-ūr´ĭ-dēn]

an antimetabolite, derived from fluorouracil and used as an antineoplastic agent by intra-arterial administration for treatment of liver metastases from gastrointestinal malignancies.

floxuridine

/flox·uri·dine/ (floks-ūr´ĭ-dēn) a derivative of fluorouracil used as an antineoplastic.

floxuridine

[floksyoo͡r′ədēn]

an antineoplastic agent.

indications It is prescribed in the treatment of metastases to the liver from colon, stomach, and other GI cancers.

contraindications Bone marrow depression, infection, poor nutritional state, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse effects leading to drug discontinuation are severe depression of the bone marrow; acute GI disturbances, including nausea, vomiting, diarrhea, and stomatitis; and myocardial ischemia. Alopecia and dermatitis commonly occur.

floxuridine

Oncology An antimetabolic fluoropyrimidine, a metabolite of 5-FU. See 5-Fluorouracil.

floxuridine

a derivative of 5-fluorouracil used as an antiviral and antineoplastic agent; abbreviated FUDR.

References in periodicals archive ?

for the treatment of non-resectable metastatic liver tumors from primary colorectal cancer in combination with adjuvant intra-hepatic artery chemotherapy using floxuridine.

Fox Chase Cancer Center Study Evaluating the Safety of Concurrent Chemotherapy and Selective Internal Radiation Therapy using SIR-Spheres[R] Microspheres Released at 2011 American Society of Clinical Oncology Annual Meeting

A further product, the FUDR(TM) brand of floxuridine, was acquired in February 2001 as we continue to build our branded portfolio and our oncology franchise.

Faulding: Half Year Announcement

International pharmaceutical company, F H Faulding & Co Limited (Faulding) today announced that Faulding Pharmaceuticals, its US-based global pharmaceuticals division, has entered into an agreement to acquire the rights to the FUDR(TM) brand of sterile floxuridine from Hoffmann-La Roche, Inc.