Wieand et al., "Intra-arterial floxuridine
vs systemic fluorouracil for hepatic metastases from colorectal cancer.
1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine
-- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.
(35) Primary sclerosing cholangitis-like injury is a relatively uncommon pattern that is mainly seen with infusion of chemotherapy agents into the hepatic artery such as floxuridine
and fluorouracil to treat metastatic colorectal cancer to the liver, as well as hepatic arterial chemoembolization in hepatocellular carcinoma.
The same group developed irinotecan: floxuridine
liposomes (CPX-1, 1: 1 molar ratio).