FLOT2

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FLOT2

A gene on chromosome 17q11-q12 that encodes a scaffolding protein present in caveolar membranes that participates in caveola and vesicle formation. It is expressed in the epidermis except the basal layer.
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Liao, "Knockdown of flotillin-2 impairs the proliferation of breast cancer cells through modulation of Akt/FOXO signaling," Oncology Reports, vol.
Several authors use different markers for microvesicles like flotillin-2, selectins, integrins, metalloproteinases, and a high level of phosphatidylserine on the outer surface (Table 1).
A search for three-dimensional structures similar to the shoulder domain using the DALI server (37) identified the core domain of stomatin from Pyrococcus horikoshii ([PhSto.sup.CD]) (PDB 3BK6) (38) and the flotillin-2 band-7 domain ([Flot.sup.BD7]) (PDB 1WIN) (Fig.