bisacodyl

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bisacodyl

 [bis-ak´o-dil]
a contact laxative used before procedures involving the colon; administered orally or by rectal suppository, either as the base or as a complex with tannic acid (bisacodyl tannex).

bisacodyl

Alophen, Apo-bisacodyl (CA), Biolax (UK), Bisac-Evac, Biscolax, Carter's Little Pills (CA), Correctol, Dacodyl, Doxidan, Dulcolax, Ex-Lax Ultra, Femilax, Fleet Bisacodyl, Fleet Stimulant Laxative, Gentlax (CA), Laxoberal (UK), Veracolate

Pharmacologic class: Stimulant laxative

Therapeutic class: Laxative

Pregnancy risk category B

Action

Unclear. Thought to stimulate colonic mucosa, producing parasympathetic reflexes that enhance peristalsis and increase water and electrolyte secretion, thereby causing evacuation of colon.

Availability

Enema: 0.33 mg/ml, 10 mg/ml

Powder for rectal solution: 1.5 mg bisacodyl and 2.5 g tannic acid

Suppositories (rectal): 5 mg, 10 mg

Tablets (enteric-coated): 5 mg

Indications and dosages

Constipation; bowel cleansing for childbirth, surgery, and endoscopic examination

Adults and children ages 12 and older: 5 to 15 mg P.O. or 10 mg P.R. as a single dose

Children older than age 3: 5 to 10 mg or 0.3 mg/kg P.O. as a single dose

Children ages 2 and older: 5 to 10 mg P.R. as a single dose

Children younger than age 2: 5 mg P.R. as a single dose

Contraindications

• Hypersensitivity to drug

• Intestinal obstruction

• Gastroenteritis

• Appendicitis

Precautions

Use cautiously in:

• hypersensitivity to tannic acid

• severe cardiovascular disease, anal or rectal fissures

• pregnant or breastfeeding patients.

Administration

• Make sure patient swallows tablets whole without chewing.

• Don't give tablets within 1 hour of dairy products or antacids (may break down enteric coating).

• Know that drug should be used only for short periods.

Adverse reactions

CNS: dizziness, syncope

GI: nausea, vomiting, diarrhea (with high doses), abdominal pain, burning sensation in rectum (with suppositories), laxative dependence, protein-losing enteropathy

Metabolic: hypokalemia, fluid and electrolyte imbalances, tetany, alkalosis

Musculoskeletal: muscle weakness (with excessive use)

Interactions

Drug-drug. Antacids: gastric irritation, dyspepsia

Drug-diagnostic tests. Calcium, magnesium, potassium: decreased levels

Phosphate, sodium: increased levels

Drug-food. Dairy products: gastric irritation

Patient monitoring

• Assess stools for frequency and consistency.

• Monitor patient for electrolyte imbalances and dehydration.

Patient teaching

• Instruct patient to swallow (not chew) enteric-coated tablets no sooner than 1 hour before or after ingesting antacids or dairy products. Tell him not to chew tablets.

• Advise patient not to use bisacodyl or other laxatives habitually because this may lead to laxative dependence.

• Suggest other ways to prevent constipation, such as by eating more fruits, vegetables, and whole grains to increase dietary bulk and by drinking 8 to 10 glasses of water daily.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

bisacodyl

(bĭs-ăk′ə-dĭl, bĭs′ə-kō′dĭl)
n.
An over-the-counter laxative taken by mouth or per rectum to treat constipation.

bisacodyl

A laxative used to manage constipation, especially in the elderly, as well as neurogenic bowel dysfunction.

Mechanism
Enteric nerve stimulation, increases fluid and salt secretion.

bisacodyl

Dulcolax An agent used to manage constipation

bisacodyl

A drug used in the treatment of constipation. A brand name is Dulco-Lax.
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