Flap endonuclease 1 | definition of flap endonuclease 1 by Medical dictionary
FEN1 (redirected from flap endonuclease 1)
FEN1 A gene on chromosome 11q12 that encodes a protein belonging to the XPG/RAD2 endonuclease family, which removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging-strand DNA synthesis. Direct physical interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides co-ordinated loading of the proteins onto the substrate, passing the substrate from one enzyme to another.
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References in periodicals archive
Flap endonuclease 1 (Fen1 in archaea or FEN-1 in eukaryotes) plays roles in both DNA replication and repair, often in conjunction with PCNA.
Yamaguchi et al., "Structural basis for recruitment of human flap endonuclease 1 to PCNA," The EMBO Journal, vol.
Interactions between APE1 and DNA polymerase [beta] or flap endonuclease 1 (FEN1) induce the removal of the remaining abasic site at the 5'-end of the cleavage site after excision of the AP site by APE1 [31, 32].
Dianov, "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair," Biochemistry, vol.