DOR is a non-nucleoside reverse transcriptase inhibitor, or NNRTI, under investigation as a single tablet for use in combination with other antiretroviral, or ARV, agents and as a fixed-dose combination
with lamivudine, or 3TC, and tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adult patients with no prior ARV treatment history.
According to the company, Trelegy Ellipta is the first once-daily single inhaler triple therapy approved for the long-term, once-daily, maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema, who are on a fixed-dose combination
of fluticasone furoate and vilanterol for airflow obstruction and reducing exacerbations in whom additional treatment of airflow obstruction is desired or for patients who are already receiving umeclidinium and a fixed-dose combination
of fluticasone furoate and vilanterol.
M2 EQUITYBITES-August 8, 2017-Mylan wins tentative approval for first fixed-dose combination
"TLD" under PEPFAR for HIV/AIDS
The fixed-dose combination
of saxagliptin and dapagliflozin has the potential to be the first DPP-4i/SGLT-2i combination product approved in Europe.
At 12 weeks, 42.5% of patients in the fixed-dose combination
therapy group were dear or almost clear, the primary study end point required by the FDA.
But by far the most dramatic change in prescribing has been the nearly threefold increase in the percentage of patients on fixed-dose combination
therapy, he noted.
to develop a fixed-dose combination
of three HIV medicines.
This fixed-dose combination
provides a dual mechanism of action in a single tablet that can address both underlying causes of hyperuricemia - overproduction and underexcretion of serum uric acid.
M2 EQUITYBITES-July 27, 2017-Mylan introduces MyHep All in India in fixed-dose combination
for treating HCV infection
In addition, Ironwood will gain the exclusive US rights to the fixed-dose combination
of lesinurad and allopurinol.
This relationship was significant when the patients were using a fixed-dose combination
in a single pill and also when they were using a free combination regimen with two concurrent pills, according to a poster presentation by Fadia T.
According to the company, TLE400 is an antiretroviral (ARV) fixed-dose combination
and will be available in developing countries as a first-line regimen for people being treated for HIV/AIDS.