FISH

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hybridization

 [hi″brid-ĭ-za´shun]
1. the production of hybrids.
fluorescent in situ hybridization (FISH) a genetic mapping technique using fluorescent tags for analysis of chromosomal aberrations and genetic abnormalities. Called also chromosome painting.
molecular hybridization in molecular biology, formation of a partially or wholly complementary nucleic acid duplex by association of single strands, usually between DNA and RNA strands or previously unassociated DNA strands, but also between RNA strands; used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands.

FISH

(fish),

fish

ichthyophobia.

fish

(fĭsh)
n. pl. fish or fishes
1. Any of numerous cold-blooded aquatic vertebrates characteristically having fins, gills, and a streamlined body and including the bony fishes, such as catfishes and tunas, and the cartilaginous fishes, such as sharks and rays.
2. Any of various jawless aquatic craniates, including the lampreys and hagfishes.
3. The flesh of such animals used as food.
Cardiology Finnish Isradipine Study In Hypertension
Molecular medicine Fluorescent In Situ Hybridization. A method for locating a segment of DNA on a chromosome. The DNA is labeled with a fluorescent dye and hybridized to a cytological preparation of chromosomes that has been denatured to allow nucleic acid hybridization between chromosomal DNA and the probe. The site of hybridization is determined by fluorescent microscopy. FISH is a hybrid of 3 technologies: cytogenetics, fluorescence microscopy, and DNA hybridization, which is used to determine cell ploidy and detect chromosome segments by evaluating interphase—non-dividing—nuclei; in FISH, fluoresceinated chromosome probes are used for cytologic analysis and cytogenetic studies, and to detect intratumoral heterogeneity. In genetics, FISH provides a physical mapping approach to detect hybridization of probes with metaphase chromosomes and with the less-condensed somatic interphase chromatin
DNA probes may be applied to cell preparations on a slide; if the complementary DNA sequence is present, it binds to DNA and can be detected by light microscopy; FISH labels probes nonradioactively either directly with fluorochromes, or indirectly with biotin and fluorochrome-labeled avidin, with digoxeginin and fluorochrome-labeled anti-digoxeginin, or others; the use of multiple band-pass filters allows simultaneous viewing of numerous probes for different chromosomal sequences labeled with different fluorochromes; FISH is useful in cytogenetic studies, where probes for particular chromosomes—e.g., chromosomes 13, 18, 21—or chromosomal regions—e.g., ABL and BCR genes in the Philadelphia translocation—can be used for the prenatal diagnosis of common aneuploidies or to detect early stages of lymphoproliferative disorders; FISH is as sensitive as other analytical techniques—e.g., conventional cytology and flow cytometry, used to diagnose transitional cell carcinoma of the urinary bladder
Pros FISH is simpler, less labor-intensive, and time-consuming—48 hours—than classic cytogenetics—karyotyping—2-3 weeks
Cons Only one question can be asked at a time, i.e., rather than asking ‘global issues’—e.g., what is the genetic composition of a population of cells

FISH

Fluorescent in situ hybridization Molecular medicine A hybrid of 3 technologies: cytogenetics, fluorescence microscopy, and DNA hybridization, which is used to determine cell ploidy and detect chromosome segments by evaluating interphase–non-dividing nuclei; in FISH, fluoresceinated chromosome probes are used for cytologic analysis and cytogenetic studies, and to detect intratumoral heterogeneity. See Chromosomal paint box.

FISH

Abbreviation for fluorescence in situ hybridization.

FISH

Abbrev for fluorescence in situ hybridization. This is a technique for detecting and locating gene mutations and chromosome abnormalities.

fish

any of a large group of cold-blooded, finned aquatic vertebrates. fish are generally scaled, and respire by passing water over gills. fish were formerly placed in a single grouping, class Pisces. It is now recognised that there are four distinct classes, ACTINOPTERYGII, (ray-finned fishes), CHOANICHTHYES (fins with central skeletal axis - collectively sometimes classed as Osteichthyes, see BONY FISH) CHONDRYCHTHYES (sharks) and APHETOHYIDEAN (extinct, primitive, jawed fish).

FISH

acronym for FLUORESCENCE IN SITU HYBRIDIZATION.

FISH

(flourescence in-situ hybridization) Technique used to detect small deletions or rearrangements in chromosomes.
Mentioned in: Prader-Willi Syndrome

Patient discussion about FISH

Q. Does fish-oil helps exercise induced asthma? I was diagnosed with exercise induced asthma a couple of year ago, and since then had better and worse times with my asthma, although the treatment I get. I read in a newspaper that fish oil can help exercise induced asthma- is that true? Do I have to eat fish-oil specifically or can I eat fish instead (I really, really, hate fish-oil…)?

A. I take 6, 1000mg softgels/day. It helps my asthma, arthritis and has lowered my closterol. Started with 10 and worked down to 6, which seems to work best, though sometimes I need the extra.

Q. Can omega-3 make my cholesterol lower? My doctor told me that I have too much cholesterol in my blood, and that it can cause heart attack or stroke, but if I keep it low than my risk will be lower. He told me that because it’s not that high level I can try to change my diet before I have to start taking medication. I heard that omega-3 can make my cholesterol level low. Is that true? Do I have to take it in pills? Is it safe?

A. You can consume omega-3 either as pills or in fish oil, fatty fish (such as salmon) and vegetarian food such as flaxseed and flaxseed oil, canola oil, soybean oil, and nuts.

More discussions about FISH
References in periodicals archive ?
The sailors may have mistaken the dugong's head and fishlike tail for the body of a mermaid.
I pointed off the road, swimming my hand fishlike to indicate a side hill descent toward the bottom, to cross and come at the elk again with the flow of morning wind in our faces.
When it was open and Rodrigo, fishlike, looked for her nipple, she pulled him away a little bit and lifted his damp shirt off him, so that all he was wearing were the thick cotton diapers that she could feel needed changing.
I realized I was the only shopper in that rather eerie place where I moved about fishlike in a glaucous aquarium.
(5) Mermaids were reduced to pure sound, since their bodies assumed a fishlike dumbness correlative to women's beauty: "Exalted by a voice that is pure voice, their embodiment treads the boards where no form of logos could trouble the feminine stereotype" (120), because "in the patriarchal symbolic order, notoriously dichotomous, where man is conceived as mind and woman as body, the partaking of logos in a pure female phone and a pure male semanthikon is coherent to the system and confirms it" (119).
While tasting vaguely fishlike they bear no resemblance to the fine product that can come from using fresh fish and selecting your ingredients carefully.
The main problem I had with the interior was that the climate control system wasn't the best - especially as it tended to emit a fishlike odour for the first few days.
During the Civil War, Democrats seemed so tainted by the stain of rebellion that one pro-Republican newspaper editor dismissed them as "a myth, a reminiscence, a voice from the tomb, an ancient, fishlike smell." Both Barry Goldwater's landslide defeat in 1964 and Watergate 10 years later seemed to threaten the Republicans with marginalization.
Thereafter, the larvae undergo metamorphosis to take on their fishlike structure and begin life on the bottom.
This resembles the work of Stanley Fish, and it's Fishlike also in so far as the difficulties in perceiving Milton's God as good are presented as the consequence of conscious poetic method; yet pleasingly un-Fishlike in that in this courtroom nothing is resolved before proceedings begin.
He has also thought of cochlear implants to enhance normal hearing, fins to make us fishlike, and echolocation devices so that we can better navigate the night.
The Greek word for fish, Ichthys, acted as an acronym for "Jesus Christ God's Son Savior." One of the great theologians went so far as to play on the idea that through the sacrament of baptism, water is the medium in which we live, so that Christians, like Jesus, are fishlike in nature.