first-line treatment


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first-line treatment

The initial, preferred, or best treatment for a disease. It is often the therapy that combines the best efficacy with the best safety profile and/or the lowest cost.
Synonym: first-line therapy
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
M2 EQUITYBITES-September 5, 2019-AstraZeneca announces approval for Tagrisso in China as first-line treatment for EGFR-mutated non-small cell lung cancer
Global Banking News-September 5, 2019-AstraZeneca announces approval for Tagrisso in China as first-line treatment for EGFR-mutated non-small cell lung cancer
M2 PHARMA-September 5, 2019-AstraZeneca announces approval for Tagrisso in China as first-line treatment for EGFR-mutated non-small cell lung cancer
Aduro Biotech announced that the first patient has been dosed in a Phase 2 clinical trial of ADU-S100, a novel STING pathway activator, in combination with KEYTRUDA, an approved anti-PD-1 antibody, as a first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma.The Phase 2, open-label, multicenter trial, which is part of an ongoing research and development collaboration with Novartis, is designed to evaluate the efficacy and safety of ADU-S100 administered intratumorally in combination with pembrolizumab in the first-line setting.
Separately, Merck said the Committee for Medicinal Products for Human Use, or CHMP, of the European Medicines Agency, or EMA, has adopted a positive opinion, recommending approval of Keytruda in combination with Pfizer Inc.(NYSE:PFE)'s Inlyta - a tyrokinase inhibitor -- for the first-line treatment of patients with advanced renal cell carcinoma, or RCC.
Food and Drug Administration has approved a new therapy for the first-line treatment of unresectable, locally advanced or metastatic malignant pleural mesothelioma.
NOTE OF CAUTION The organisation says it is updating its HIV therapy guidelines to strengthen its recommendation for dolutegravir (DTG) drug as the first-line treatment because of its efficacy, tolerability and a high genetic barrier to resistance.
INDIANAPOLIS -- The Food and Drug Administration has granted approval for a new indication for Eli Lilly and Co.'s Alimta (pemetrexed for injection) in combination with Keytruda (pembrolizumab), developed and marketed by Merck & Co., and platinum chemotherapy for the first-line treatment of patients with metastatic nonsquamous non-small-cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations.
The take-home message: The findings support current guidelines that physical therapy can be an appropriate alternative to arthroscopic surgery as first-line treatment for patients with nonobstructive meniscal tears.
Several treatment guidelines state that nonpharmacological options should be the first-line treatment for anxiety, agitation and insomnia in people with dementia.
Pfizer's NDA for palbociclib, in combination with letrozole, has been accepted for filing and granted Priority Review by the FDA as a first-line treatment for postmenopausal women with estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer who have not received previous treatment.