first-line


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first-line

(fûrst′līn′)
adj.
1.
a. Relating to or being the initial stage of something: the body's first-line defense against infection.
b. Being a drug or therapy that is the standard or initial treatment for a disease or condition.
2. Performing the most basic tasks or interacting directly with customers, patients, or clients; frontline.
References in periodicals archive ?
Joel Saban, Diplomat president, said, 'In supporting patients with advanced renal cell carcinoma, we are pleased to offer CABOMETYX as a new first-line treatment option.
The European Comission (EC) has approved expanding the use of Novartis' (VTX: NOVN) Zykadia (ceritinib) to include the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumours are anaplastic lymphoma kinase (ALK)-positive, the company disclosed on Thursday.
The first-line approval of Zykadia is based on results from an open-label, randomized, multicenter, global, Phase III trial, ASCEND-4.
In the face of so many different formulations available in pharmacies across the country, ensuring the correct prescription of first-line TB drugs in the private sector is almost an impossible task for the Central TB Division (CTD).
Some migraine medications work better in treatment-naive patients, compared with those with a past marred by partial responses or one or more failures to first-line prophylactic therapies.
The lower price could well be in the company's financial interest, by allowing first-line use if the drug proves suitable--especially important now that its rival Aptivus (tipranavir) does not seem to be working well as a first-line treatment, with a clinical trial stopped because of performance that appeared slightly inferior to a good standard treatment based on Kaletra.
Currently, there is no effective treatment for patients with aggressive NHL that have relapsed following first-line and second-line treatment.
The authors performed a meta-analysis of randomized controlled trials comparing CCBs with first-line antihypertensives regarding their effects on cardiovascular events.
In a retrospective study of 5,526 new TB cases from 1994 to 1996 in the Dominican Republic, Hong Kong, Italy, Ivanovo Oblast (Russia), Korea, and Peru, resistant strains contributed to a failure rate of 21% and a mortality rate of 9% in areas using the World Health Organization's directly observed short-course regimen with five first-line drugs (JAMA 283[19]:2537-45, 2000).
The small differential between team leaders and first-line supervisors is best explained by looking at their occupations.
7) If COPPS is to be implemented successfully, mid-level managers must provide administrative support and remove any barriers that first-line supervisors may confront.
Of primary importance is the issue of preparing first-line supervisors for their new role as managers in the direct supervision philosophy.