first-line


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first-line

(fûrst′līn′)
adj.
1.
a. Relating to or being the initial stage of something: the body's first-line defense against infection.
b. Being a drug or therapy that is the standard or initial treatment for a disease or condition.
2. Performing the most basic tasks or interacting directly with customers, patients, or clients; frontline.
References in periodicals archive ?
hospitals, ceftazidime-avibactam, meropenem-vaborbactam, or plazomicin were positioned as first-line agents against CRE pneumonia, bacteremia, intra-abdominal infections, and urinary tract infections, respectively.
As a result, countries like Kenya halted plans to make DTG-based regimens the preferred first-line therapy.
- Japan's Pharmaceuticals and Medical Devices Agency has approved Lynparza as a maintenance treatment after first-line chemotherapy in patients with BRCA-mutated (BRCAm) ovarian cancer, British-Swedish drugmaker AstraZeneca and US-based Merck (NYSE: MRK) said.
Pharmaceutical and biopharmaceutical company AstraZeneca Plc (LSE:AZN) and MSD Inc (Merck & Co Inc in the US and Canada) (NYSE:MRK) announced on Wednesday the approval for Lynparza in Japan as a maintenance treatment after first-line chemotherapy in patients with BRCA-mutated (BRCAm) advanced ovarian cancer, as detected by an approved companion diagnostic test.
Release date- 18062019 - KENILWORTH - AstraZeneca and Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European Commission has approved LYNPARZA as monotherapy for the maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (BRCAm) (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy.
Patients who were on alternative first-line therapy, lost for follow-up, infected with HIV 2 and expired were excluded from the study.
She said that findings of the study indicated that at least two other first-line drugs need to be taken on fasting aside rifampicin, adding that the findings are significant as the dosage of first-line drugs is low.
(8,10) To date, the immune checkpoint inhibitors have been approved for second-line therapy of advanced NSCLC after progression on first-line therapies.
India has the largest private TB drug market, with rampant proliferation of first-line TB drugs in a wide variety of dosages and combinations.
However, there was no significant improvement in terms of OS, probably because most patients treated in the placebo arm crossed over to the EV arm.[sup.6] In 2012, Chen and colleagues published a real-world data analysis of 257 patients with mRCC who were receiving second-line EV, sorafenib (SO), or TM after first-line SU.
The ACR urate-lowering algorithm begins with either allopurinol or febuxostat (Uloric) as first-line therapy.