first-generation cephalosporin


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first-generation cephalosporin

Any of a group of cephalosporin antibiotics capable of killing gram-positive cocci such as Staphylococcus aureus, streptococci, and some aerobic gram-negative rods. These agents are used to treat skin and soft tissue infections, uncomplicated respiratory tract infections, and urinary tract infections. Examples of first-generation cephalosporins are cephalothin, cephaloridine, cephapirin, cefazolin, cephradine, cephalexin, and cefadroxil.
See also: cephalosporin
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
In the overall group of 611 children with UTI, trimethoprim-sulfamethoxazole was prescribed for 61%, amoxicillin for 29%, nitrofurantoin for 7%, and other antimicrobials including first-generation cephalosporins for the other 3%.
According to the recent IDSA guidelines, erythromycin is identified as a suitable alternative for patients allergic to penicillin; first-generation cephalosporins are also recommended, providing the patient does not have immediate-type hypersensitivity to [beta]-lactam antibiotics.
(38,40) However, the early first-generation cephalosporins included in this analysis were produced by the Cephalosporium mold and actually contained trace amounts of penicillin.
The increased risk of allergic reactions in penicillin-allergic patients is only 0.4% for first-generation cephalosporins and "nearly nil" for certain later-generation agents, which he defined as cefdinir, cef-podoxime, and cefuroxime.
When the first-generation cephalosporins cephaloridine and cephalothin were introduced in the 1960s, allergic and anaphylactic reactions were reported in patients with previous allergic reactions to penicillins.
For example, first-generation cephalosporins have activity against most strains of MSSA but nearly all MRSA isolates are resistant.
When the 1978 paper was published, only first-generation cephalosporins were available.