A protein that structurally resembles mannose-binding lectin (MBL). The polypeptide chains have a N-terminal region, a collagenlike domain, and a globular region, which is fibrinogenlike. Although H-ficolin and L-ficolin are plasma proteins generated in the liver, M-ficolin is produced by monocytes, and is membrane bound. H- and L-ficolin can form oligomers and are capable of activating complement. M-ficolin may act as a phagocytic receptor on circulating monocytes for glycosylated proteins.
See also: L-ficolin, H-ficolin.
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QRT-PCR analysis indicated the transcription of the selected lncRNAs: RP11-517C16.2-001, FR271872, LOC283352, RP11-401E9.3, FGFR3P, XXbac-BPG16N22.5, and mRNAs: collagen 19a1 (COL19A1), nitric oxide synthase 2 (NOS2), chromosome 13 open reading frame 15 (C13orf15), FBJ murine osteosarcoma viral oncogene homolog (FOS), ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (FCN2), serine peptidase inhibitor, Kunitz type 1 (SPINT1), placenta-specific 8 (PLAC8), E2F transcription factor 1 (E2F1), and baculoviral IAP repeat containing 5 (BIRC5), perfectly correlated to microarray results.
Ficolins. Three members of the ficolin family of proteins have been described in humans, such as L-ficolin (or ficolin-2), H-ficolin (or ficolin-3 or Hakata antigen), and M-ficolin (or ficolin-1) [16-19].
Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia.
LP is activated by binding of mannose binding lectin (MBL) or ficolin to pathogen-associated molecular patterns (PAMPs) on the surface of microbes.
After blocking the endogenous peroxidase with 30 g/L hydrogen peroxide, for ficolin staining alone, sections were incubated in TBS with normal sheep serum, with either H-ficolin monoclonal antibody (clone 4H5) from HyCult Biotechnology or rabbit polyclonal anti-L-ficolin antibody (clone 2F5) from Tokai University.
The lectin pathway can be initiated by the collectins MBL, CL-K1, and CL-LK and all the ficolins [11, 12].
Thiel, "Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins," Molecular Immunology, vol.
These include complement components, collectins, ficolins, and pentraxins.
Just in mammalian species calreticulin was reported as a receptor for C1q mannose-binding lectins and ficolins
Innate immunity consists of a highly regulated immune surveillance system comprising several humoral factors, including soluble PRRs, such as collectins, ficolins, and pentraxins [32, 33], and the complement cascade [34].
Conversely, particles coated with poloxamine in the mushroom-brush and fully brush conformation activate the complement via the lectin pathway, which involves the opsonisation of mannose-binding lectin protein (MBL) and/or ficolins. This complement activation pathway was attributed to the structural similarities between the EO monomers of poloxamine and a region of D-mannose [144].