Cal, "The dual role of fibulins in tumorigenesis," Cancer Letters, vol.
Fibulin-3, an extracellular matrix protein, is a member of the fibulin family and a disulfide-rich glycoprotein encoded by epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) .
Kjaer, "Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins
, fibrinogen, fibronectin, laminin, tenascins and thrombospondins," Advances in Experimental Medicine and Biology, vol.
(FBLN) are elastin-binding proteins that associate with fibronectin-containing fibers and lamina within the aorta and other large arteries .
Gallagher, "Fibulins: physiological and disease perspectives," EMBO Reports, vol.
Out of these eight genes, amphiregulin (AREG), fibulin 1 (FBLN1), and claudin 6 (CLDN6) were the most differentially expressed.
Davis et al., "Fibrillins, fibulins
, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide," Biochemistry, vol.
Fibulin-2 belongs to fibulins, which are components of basement membranes and elastic matrix fibers in connective tissue and also play a role in tumorigenesis [134-136].
Segade, "Molecular evolution of the fibulins: implications on the functionality of the elastic fibulins, " Gene, vol.
Otherwise, no information is available about elastin and elastin-associated matrix molecules, such as fibulins, in relation to diabetic arteriopathy.
We performed quantitative real-time PCR (q-RT-PCR) using random hexamer primers and Taqman gene expression assays (Applied Biosystems Prism 7700) for von Willebrand factor (VWF)12 (Hs01109460_m1); leptin (LEP) (Hs00174877_m1); matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2) (Hs00234422_m1); fibulin 1 (FBLN1) (Hs00242546_m1); and fibulin 2 (FBLN2) (Hs01002054_m1).
Microfibrils are composed mainly from fibrillin and several microfibril-associated proteins (elastin microfibril interface-located protein 1 (Emilin-1), microfibril-associated glycoproteins (MAGP-1,2), and fibulins