The extracellular matrix of tumors: a focus on fibronectin and fibulin-5
. In: Brekken RA, Stupack D, editors.
Yanagisawa et al., "Identification of the matricellular protein Fibulin-5
as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets," Scientific Reports, vol.
observed decreased fibulin-4 expression in patients with anetoderma or MDE, whereas decreased fibulin-5
expression was only observed in patients with MDE .
Landreneau et al., "Fibulin-5
suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression," Cancer Research, vol.
Elastin is made from its precursor molecule tropoelastin, which forms elastic fibers after key steps involving the enzyme lysyl oxidase-like 1 (LOXL1) and glycoprotein fibulin-5
Rare forms of AMD, exhibiting an autosomal dominant pattern of inheritance, may be related to the fibulin-5
"We found that the protein fibulin-5
, which until now simply has been known to be important in generating elastic fibers, actually blocks the enzymes that degrade proteins that support the vaginal wall structure," explains gynecologist R.
mutations: mechanism of impaired elastic fibre formation in recessive cutis laxa.
Also new from LS is Elestan, a Manilkara extract that works four ways in anti-aging products: it has an anti-glycation effect, protects against elastases, stimulates (tropo) elastin synthesis and ensures optimal structuring of the elastic fiber network through the stimulation of Emilin-1 and Fibulin-5
, both of them elastin-associated proteins.
Starcher et al., "Fibulin-5
is an elastin-binding protein essential for elastic fibre development in vivo," Nature, vol.
One of the main reasons elastin production decreases as we age is due to diminishing levels of the enzymes lysyl oxidase-like 1 (LOXL1) and glycoprotein fibulin-5
Shi et al., "Pelvic organ support in animals with partial loss of fibulin-5
in the vaginal wall," PLoS ONE, vol.