fibulin 1

fibulin 1

A secreted glycoprotein incorporated into a fibrillar extracellular matrix by laminin and nidogen binding. Fibulin servs several functions, including cell adhesion and migration along protein fibres within the ECM; it may be critical for developmental processes and contribute to the ECM supramolecular organisation, especially of basement membranes. It has been implicated cell transformation and tumour invasion, and may be a tumour suppressor. It may also play a role in haemostasis and thrombosis by binding fibrinogen and incorporating itself into blood clots, as well as in modulating the neurotrophic activities of APP, especially soluble APP.
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References in periodicals archive ?
generating a transcriptional profile from the first and second human skin samples of a set of genes consisting of fibrillin 1 (FBNl), fibulin 1 (FBLNl), tenascin XB (TNXB), fibronectin 1 (FNl), lysyl oxidase homolog 2 (LOXL2), collagen, type I, alpha 1 (COLlAl), collagen, type III, alpha 1 (COL3Al), elastin (ELN) and Iysyl oxidase-like 1 (LOXLl);
Liu et al., "Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer," British Journal of Cancer, vol.
Out of these eight genes, amphiregulin (AREG), fibulin 1 (FBLN1), and claudin 6 (CLDN6) were the most differentially expressed.
Fibulin 1 (FBLNI) is the prototype member of the fibulin family of ECM proteins and binds to many ECM proteins, including fibronectin, laminin-1, fibrinogen, aggrecan, and versican.
We performed quantitative real-time PCR (q-RT-PCR) using random hexamer primers and Taqman gene expression assays (Applied Biosystems Prism 7700) for von Willebrand factor (VWF)12 (Hs01109460_m1); leptin (LEP) (Hs00174877_m1); matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2) (Hs00234422_m1); fibulin 1 (FBLN1) (Hs00242546_m1); and fibulin 2 (FBLN2) (Hs01002054_m1).
[12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.