fibrosis of the lungs

fibrosis of the lungs

Etymology: L, fibra + Gk, osis, condition; AS, lungen
the formation of scar tissue in the connective tissue of the lungs as a sequel to any inflammation or irritation caused by tuberculosis, bronchopneumonia, or a pneumoconiosis. Localized fibrosis may be complicated by infarction, abscess, or bronchiectasis. Also called pulmonary fibrosis.

Patient discussion about fibrosis of the lungs

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A. Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: Hope this helps.

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References in periodicals archive ?
Multiple organ systems can be affected, resulting in pancreatitis, retroperitoneal or mediastinal fibrosis, sclerosing cholangitis, and fibrosis of the lungs, parotid glands, and lacrimal glands.
An important indirect effect of interstitial lung disease, a broad category of lung diseases that includes some 150 disorders characterized by scarring or fibrosis of the lungs, is on the pulmonary vasculature with resulting pulmonary hypertension.
A post mortem examination conducted by Dr Campbell Ritchie found that Mr Wallace had inhaled carbon particles from the steel which had caused fibrosis of the lungs, the inquest heard.
Cooke reported on fibrosis of the lungs caused by asbestos inhalation in 1924, but the term "asbestosis" was first used to describe it in 1927 (Cooke 1924, 1927).
Fibrosis of the lungs due to inhalation of asbestos.
In pulmonology InterMune is developing therapies for treating idiopathic pulmonary fibrosis, a disease characterized by progressive scarring or fibrosis of the lungs (which ultimately results in death) and for which there is no approved therapy.