fibronectins


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Related to fibronectins: plasma fibronectin

fi·bro·nec·tins

(fī'brō-nek'tinz),
High molecular weight multifunctional glycoproteins found on cell surface membranes and in blood plasma and other body fluids. Fibronectins are thought to function as adhesive ligandlike molecules that play a role in contact inhibition; also known as large external transformation sensitive protein (LETS), which is reduced after cells become transformed.
Synonym(s): zetaprotein
[L. fibra, fiber, + nexus, interconnection]

fibronectins

A family of glycoproteins occurring on cell surfaces, in most basement membranes and in blood and other body fluids. They are binding molecules that link to specific receptors on and within cells. They are involved in platelet aggregation and in the determination of cell shape and the formation of tissues. Fibronectin inhibitor drugs have been developed.

fi·bro·nec·tins

(fī'brō-nek'tinz)
High molecular weight multifunctional glycoproteins found on cell surface membranes and in blood plasma and other body fluids.
[L. fibra, fiber, + nexus, interconnection]
References in periodicals archive ?
Fibronectin regulated the DNA synthesis of fibroblasts.
Fibronectin up-regulated the collagen synthesis of fibroblasts.
The increasing osteocalcin amount showed the osteogenesis capacity of fibroblasts induced by fibronectin. There was no statistical significance among groups at day 4 (P>0.05).
Ruoslahti, "Fibronectin synthesis by epithelial crypt cells of rat small intestine," Proceedings of the National Academy of Sciences of the United States of America, vol.
Dontenwill, "Integrin alpha5-beta1, the fibronectin receptor, as a pertinent therapeutic target in solid tumors," Cancers (Basel), vol.
The physical niche includes collagen fibres, integrins, fibronectin filaments, laminins, and glycosaminoglycan, which form a highly structured network named as the extracellular matrix (ECM).
In a typical cell attachment assay, 96-well plates are coated with the indicated concentrations of fibronectin in 50 mM sodium bicarbonate buffer pH 9.6 (coat buffer).
Lab-Tek chamber slides are previously coated with 0.0, 0.2, or 0.4 [micro]g/mL of fibronectin in coat buffer overnight at 4[degrees]C and then a second coat of 3 [micro]g/mL MGP for 3 hours at 37[degrees]C and then blocked with heat inactivated BSA-PBS for 1.5 h at 37[degrees]C as described above.
MGP Binds to Fibronectin and the First Type III Domain of Fibronectin.
Among COPD patients, a significant correlation between lung function and the abundance of fibronectin and elastic fibers has been reported.
The role of ECM components such as elastin, fibronectin, and HA in COPD may be further evaluated by measuring enzyme expression and plasma concentrations of ECM components.
[20.] Hayashi M, Yamada KM (1983) Domain structure of the carboxyl-terminal half of human plasma fibronectin. J Biol Chem 258: 3332-3340.