fibronectin


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fibronectin

 [fi″bro-nek´tin]
an adhesive glycoprotein: one form circulates in plasma and acts as an opsonin, and another is a cell-surface protein that mediates cellular adhesive interactions.

fibronectin

(fī′brə-nĕk′tn)
n.
Any of a group of glycoproteins that are found especially in blood plasma and in the extracellular matrix of connective tissue and that play a role in cellular adhesion, embryonic differentiation, phagocytosis, and blood clotting.

FN1

A gene on chromosome 2q34 that encodes fibronectin, a glycoprotein present as a soluble dimer in plasma, and as a dimer or multimer on cell surfaces and in extracellular matrices. It plays central roles in cell adhesion and motility as required in embryogenesis, wound healing, blood coagulation, opsonisation, host defence, maintenance of cell shape and metastasis. It binds to collagen, fibrin, heparin, DNA and actin.

fi·bro·nec·tin

(fī'brō-nek'tin)
Any of various glycoproteins found on cell membranes and in blood and other body fluids; thought to function as adhesive ligandlike molecules. Possible roles in other processes include transformation to malignancy. Deficiency of fibronectin is associated with Ehlers-Danlos syndrome.
[L. fibra, fiber, + nexus, interconnection]

Patient discussion about fibronectin

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More discussions about fibronectin
References in periodicals archive ?
Concomitant increases in N-cadherin and Fibronectin were evident in predominantly elongated fibroblast-like cells.
Inhibition of fibronectin binding to matrix components by nonenzymatic glycosylation.
cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis.
PCL ([M.sub.W]: 80 kD) and human plasma fibronectin were obtained from Sigma Aldrich (Saint Louis, MO) as well as all reagents used in functionalization.
Another study examined the prognostic significance of versican, the proteoglycan linking HA, collagen I, fibronectin, and laminin within the ECM [93].
Corticosteroids increase expression of extracellular matrix proteins, fibronectin, polymerised glycosaminoglycans and elastin with their accumulation in the trabecular meshwork, obstructing the outflow pathway.18 The endothelial cells of trabecular meshwork are phagocytic, removing debris from meshwork.
Extracellular matrix components such as fibronectin and matrix metalloproteinases also play a crucial role during development especially in developing cell to cell junctions.
Together they show a novel mechanism of estrogen receptor signalling that is regulated by fibronectin. It was found that exposure to fibronectin prolongs the activity of estrogen receptors in breast cancer cells.
The a-subunit contains a Leurich-compositionally biased region, Cys-rich-compositionally biased region, a Fibronectin type-III 1-domain and an insulin in-binding-region.
Another component of ECM is Fibronectin (FN), which is one of the most important ligands for [beta]1-integrins found in bivalve genome [25,27].
(7) In particular, fibronectin and vitronectin (ECM proteins) induce the formation of spheroids, adherence, and disaggregation of ovarian cancer cells.