fibrogenesis


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Related to fibrogenesis: fibrosis, fibrose

fi·bro·gen·e·sis

(fī'brō-jen'ĕ-sis),
The production or development of fibers.

fibrogenesis

The synthesis of “fibrous” tissue, including collagen and elastic fibres.
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The increase in VEGF in the urine of MS patients with hypertension is accompanied by an increase in MAU, hyper-leptinemia and increased resistin and a decrease in GFR, which may be due to the activation of fibrogenesis and endothelial dysfunction, which has a damaging effect on the glomerulus.
EGFR activation is known to mediate fibrogenesis, and it is stimulated by its ligands to mediate the fibrogenic effects of many other factors in CKD (Zhuang and Liu 2014).
Hypoxia-inducible factor-2alpha and TGF-beta signaling interact to promote normoxic glomerular fibrogenesis.
Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice.
b) Immunohistochemistry: Hematopoietic stem cells (HSCs) represent the key source of fibrogenesis.
Strikingly, when foci of severe parenchymal fibrosis were detectable in the lobules, a discrete localization of FVIIIRAg immunoreactivity was observed in the lesion (Figures 8(a) and 8(b)), which suggests the involvement of sinusoidal transformation in liver fibrogenesis.
Ultimately, renal fibrogenesis is a major mechanism of kidney impairment in multiple myeloma [23].
To test this, LX-2 cells were treated with TCDD in both the absence and presence of transforming growth factor beta (TGF-[beta]) to induce fibrogenesis or the pro-inflammatory cytokine interleukin-1 beta (IL-1[beta]).
The authors identify a role for two key compounds produced by mast cells-histamine and renin-and propose that they promote fibrogenesis when mast cells are activated early in the course of the disease.
CTGF, intestinal stellate cells and carcinoid fibrogenesis.
Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment.