Desmoplastic fibroblastoma is an uncommon benign soft-tissue tumor, which was first described by Evans in 1995.
Of the 16 cases of soft-tissue desmoplastic fibroblastoma, 15 were obtained from surgical procedures in the Department of Hand Surgery and one case of bone was derived from a surgical procedure in the Department of Orthopedic Oncology.
Formalin-fixed, paraffin-embedded specimens of 16 cases of desmoplastic fibroblastoma were available for immunohistochemical analysis.
In the one case of desmoplastic fibroblastoma of bone, the X-ray of the right proximal femur showed an osteolytic lesion with a well-defined sclerotic rim, but lack of matrix calcification [Figure 1]b.
The schwannoma, also known as neurilemmoma, neurinoma, or perineural fibroblastoma
, is a slow-growing benign neoplasm of the peripheral nerves usually located in soft tissues; (1) it is composed of Schwann cells, which is a type of glial cell surrounding the axon of the neurons and forming the myelin sheath, mainly in charge of correctly guide the axon growth.
114) Many histologic variants of DFPS have been described, including giant cell fibroblastoma (115) and those with fibrosarcomatous changes (DFSPFS), associated with a significantly more aggressive clinical course.
Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group.
Interestingly, other neoplasms with fibroblastic/myofibroblastic differentiation evaluated by these authors (DFSP, LGFS, desmoplastic fibroblastoma
, and fibromatosis) did not express this antigen.
Giant cell fibroblastoma (GCF) is a recently described, locally recurring childhood tumor of the superficial soft tissues.
Giant cell fibroblastoma is an uncommon soft tissue tumor of childhood that was first described by Schmookler and Enzinger.
Secondary elements are usually absent Giant cell fibroblastoma Bland spindle to oval cells entrapped (present case) in a metachromatic matrix; may be accompanied by multinucleated giant cells with wreathlike nuclei Miscellaneous Leiomyomas .
Various regions within the alpha- helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas