In 2013, Carter and colleagues (12) studied 18 cases of low-grade fibroblastic
tumor of the superficial soft tissue that have distinctive clinical and pathologic features not described in previous literature.
Intra-alveolar organizing fibroblastic
tissue, some with central fibrinous cores, may be seen but should not constitute the dominant finding, as in cases of OP.
In the first month, minimal fibroblastic
proliferation accompanied by capillary proliferation was determined in 3 subjects in the control group, and moderate proliferation was determined in 2.
The spindle-like shaped cells strongly attached to the surfaces of the flask like the fibroblastic
cells and were also varied size (40 +- 20 um in length and 10 +- 2um) (Figure 1).
MIFS is defined as a locally aggressive fibroblastic
neoplasm that occurs primarily in distal extremities and is characterized by epithelioid fibroblasts with macronucleoli interspersed with a prominent mixed inflammatory infiltrate and variable myxoid matrix.
(B) Significant peribronchiolar interstitial expansion by chronic inflammation associated with loose fibroblastic
tissue (star) (100x magnification).
Giant solitary fibrous tumors of the pleura are part of a broad class of fibroblastic
lesions that can occur nearly anywhere in the body.
Histopathological examination revealed fibroblastic
proliferation with fibroblast arranged in whirling pattern with infiltration of eosinophils.
Thus, according to Cushing and Bailey classification, realized in 1928, the meningiomas have been categorized into four types (meningothelial, fibroblastic
, angioblastic, and osteoblastic), while Russell and Rubinstein, in 1971, have proposed a five-type classification (syncytial, transitional, fibroblastic
, angioblastic, and mixed type) .
Positive immunoreactivity was observed in all osteosarcomas except a fibroblastic
variant, as shown in Table 2.
Fibroma of the tendon sheath (FTS) is a benign fibroblastic
neoplasm that most often presents as a circumscribed nodular mass around small joints and involves the tendon and tendon sheaths of the fingers, hands, and wrist .
IPF is characterized histologically by the presence of fibroblastic
foci, which are believed to be the site of active tissue remodeling and deposition of extracellular matrix proteins due to presence of activated fibroblasts or myofibroblasts.